ArticleMolecular and cellular biology2004
Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 84 citations in OpenAlex.
- C-Terminal Extended Domain-Independent Telomere Maintenance: Modeling the Function of TIN2 Isoforms inInternational journal of molecular sciences · 2025Article
- Potential effects of assisted reproductive technology on telomere length and telomerase activity in human oocytes and early embryos.Journal of ovarian research · 2023Review
- Damage-Free Shortening of Telomeres Is a Potential Strategy Supporting Blind Mole-Rat Longevity.Genes · 2023Article
- Editing TINF2 as a potential therapeutic approach to restore telomere length in dyskeratosis congenita.Blood · 2022Article
- TIN2 deficiency leads to ALT-associated phenotypes and differentiation defects in embryonic stem cells.Stem cell reports · 2022Article
- Genetic and Epigenetic Inheritance at Telomeres.Epigenomes · 2022Review
- Rap1 regulates TIP60 function during fate transition between two-cell-like and pluripotent states.Genes & development · 2022Article
- TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA.Nucleic acids research · 2021Article
- Telomeres and Cancer.Life (Basel, Switzerland) · 2021Review
- Genetics and animal models of familial pulmonary fibrosis.International immunology · 2021Review
- The end protection problem-an unexpected twist in the tail.Genes & development · 2021Article
- The role of telomere-binding modulators in pluripotent stem cells.Protein & cell · 2020Review
- Article
- Age-related response to an acute innate immune challenge in mice: proteomics reveals a telomere maintenance-related cost.Proceedings. Biological sciences · 2018Article
- Implications of telomeres and telomerase in endometrial pathology.Human reproduction update · 2017Review
- Systematic analysis of human telomeric dysfunction using inducible telosome/shelterin CRISPR/Cas9 knockout cells.Cell discovery · 2017Article
- The shelterin complex and hematopoiesis.The Journal of clinical investigation · 2016Review
- Gene dosage reductions of Trf1 and/or Tin2 induce telomere DNA damage and lymphoma formation in aging mice.Leukemia · 2016Article
- Telomere-regulating genes and the telomere interactome in familial cancers.Molecular cancer research : MCR · 2015Review
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
TIN2 is a negative regulator of telomere elongation that interacts with telomeric DNA repeat binding factor 1 (TRF1) and affects telomere length by a telomerase-dependent mechanism. Here we show that inactivation of the mouse TRF1-interacting protein 2 (TIN2) gene results in early embryonic lethality. We further observed that the embryonic lethality of TIN2 mutant mice was not affected by inactivation of the telomerase reverse transcriptase gene, indicating that embryonic lethality is not the result of telomerase-dependent changes in telomere length or function. Our findings suggest that TIN2 has a role independent of telomere length regulation that is essential for embryonic development and cell viability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.