Evidence map›Paper›PMID 15254226›Full record

ArticleMolecular and cellular biology2004

Metastasis-associated protein 1 interacts with NRIF3, an estrogen-inducible nuclear receptor coregulator.

Amjad H Talukder, Anupama Gururaj, Sandip K Mishra, Ratna K Vadlamudi, Rakesh Kumar

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. The NuRD architecture.Cellular and molecular life sciences : CMLS · 2013
    Review
  6. Article
  7. E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1.Proceedings of the National Academy of Sciences of the United States of America · 2009
    Article
  8. Review
  9. Article
  10. Review
  11. Corepressors of agonist-bound nuclear receptors.Toxicology and applied pharmacology · 2007
    Review
  12. Review
  13. MTA1, a transcriptional activator of breast cancer amplified sequence 3.Proceedings of the National Academy of Sciences of the United States of America · 2006
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Amjad H TalukderDepartments of Molecular and Cellular Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
Anupama Gururaj
Sandip K Mishra
Ratna K Vadlamudi
Rakesh Kumar
The University of Texas MD Anderson Cancer Center · US

Funding

Role of Metastatic Tumor Antigen-1 in Mammary GlandR01CA098823 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KUMAR, RAKESH · 2003 to 2013
$3.1M
Pak1 - PIN Pathway in Breast Cancer ProgressionR01CA080066 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KUMAR, RAKESH · 1999 to 2008
$2.3M
RECEPTOR BLOCKADE FOR BREAST CANCERR01CA065746 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KUMAR, RAKESH · 1999 to 2007
$1.9M
LABORATORY STUDY OF CHEMOTHERAPY PLUS RECEPTOR BLOCKADEU01CA065746 · NCI · UNIVERSITY OF TEXAS MD ANDERSON CAN CTR · PI KUMAR, RAKESH · 1995 to 1998
–
NCI NIH HHS CA 098823NCI NIH HHS CA 65746NCI NIH HHS CA 80066NCI NIH HHS R01 CA065746NCI NIH HHS R01 CA080066NCI NIH HHS R01 CA098823NCI NIH HHS U01 CA065746
6 · The paper itself

Abstract

The transcriptional activity of estrogen receptor alpha (ER-alpha) is modified by regulatory action and interactions of coactivators and corepressors. Recent studies have shown that the metastasis-associated protein 1 (MTA1) represses estrogen receptor element (ERE)-driven transcription in breast cancer cells. With a yeast two-hybrid screen to clone MTA1-interacting proteins, we identified a known nuclear receptor coregulator (NRIF3) as an MTA1-binding protein. NRIF3 interacted with MTA1 both in vitro and in vivo. NRIF3 bound to the C-terminal region of MTA1, while MTA1 bound to the N-terminal region of NRIF3, containing one nuclear receptor interaction LXXLL motif. We showed that NRIF3 is an ER coactivator, hyperstimulated ER transactivation functions, and associated with the endogenous ER and its target gene promoter. MTA1 repressed NRIF3-mediated stimulation of ERE-driven transcription and interfered with NRIF3's association with the ER target gene chromatin. In addition, NRIF3 deregulation enhanced the responsiveness of breast cancer cells to estrogen-induced stimulation of growth and anchorage independence. Furthermore, we found that NRIF3 is an estrogen-inducible gene and activated ER associated with the ER response element in the NRIF3 gene promoter. These findings suggest that NRIF3, an MTA1-interacting protein, is an estrogen-inducible gene and that regulatory interactions between MTA1 and NRIF3 might be important in modulating the sensitivity of breast cancer cells to estrogen.

Indexed as

Amino Acid MotifsBlotting, NorthernBlotting, WesternCell DivisionCell Line, TumorChromatinDNA, ComplementaryEstrogen Receptor alphaEstrogensGene DeletionGlutathione TransferaseHistone DeacetylasesHumansModels, GeneticNuclear ProteinsOligonucleotide Array Sequence AnalysisChromatinDNA, ComplementaryEstrogen Receptor alphaEstrogensGlutathione TransferaseHistone DeacetylasesITGB3BP protein, humanMTA1 protein, humanNuclear ProteinsReceptors, EstrogenRepressor ProteinsRNA, Small InterferingTrans-Activators

Identifiers

PMID15254226
PMCPMC444867
OpenAlexW2111611782

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.