ArticleJournal of virology2004
Itinerary of hepatitis B viruses: delineation of restriction points critical for infectious entry.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Hepatitis B virus entry, assembly, and egress.Microbiology and molecular biology reviews : MMBR · 2024Review
- Pathogenicity and virulence of Hepatitis B virus.Virulence · 2022Review
- Early Steps of Hepatitis B Life Cycle: From Capsid Nuclear Import to cccDNA Formation.Viruses · 2021Review
- Synchronised infection identifies early rate-limiting steps in the hepatitis B virus life cycle.Cellular microbiology · 2020Article
- Article
- Comparative Transcriptomic Analysis of Primary Duck Hepatocytes Provides Insight into Differential Susceptibility to DHBV Infection.PloS one · 2016Article
- Duck Hepatitis B Virus cccDNA Amplification Efficiency in Natural Infection Is Regulated by Virus Secretion Efficiency.PloS one · 2015Article
- Identification and characterization of a novel bipartite nuclear localization signal in the hepatitis B virus polymerase.World journal of gastroenterology · 2013Article
- Article
- The association of viral proteins with host cell dynein components during virus infection.The FEBS journal · 2011Review
- Proteomic analysis of primary duck hepatocytes infected with duck hepatitis B virus.Proteome science · 2010Article
- Initiation of hepatitis C virus infection requires the dynamic microtubule network: role of the viral nucleocapsid protein.The Journal of biological chemistry · 2009Article
- Duck hepatitis B virus requires cholesterol for endosomal escape during virus entry.Journal of virology · 2008Article
- Avian hepatitis B viruses: molecular and cellular biology, phylogenesis, and host tropism.World journal of gastroenterology · 2007Review
- Viral and cellular determinants involved in hepadnaviral entry.World journal of gastroenterology · 2007Review
- Intracellular transport of hepatitis B virus.World journal of gastroenterology · 2007Review
- Eclipse phase of herpes simplex virus type 1 infection: Efficient dynein-mediated capsid transport without the small capsid protein VP26.Journal of virology · 2006Article
- Lipid-mediated introduction of hepatitis B virus capsids into nonsusceptible cells allows highly efficient replication and facilitates the study of early infection events.Journal of virology · 2006Article
- Identification of a structural motif crucial for infectivity of hepatitis B viruses.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- A hydrophobic domain in the large envelope protein is essential for fusion of duck hepatitis B virus at the late endosome.Journal of virology · 2005Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Little is known about cellular determinants essential for human hepatitis B virus infection. Using the duck hepatitis B virus as a model, we first established a sensitive binding assay for both virions and subviral particles and subsequently elucidated the characteristics of the early viral entry steps. The infection itinerary was found to initiate with the attachment of viral particles to a low number of binding sites on hepatocytes (about 10(4) per cell). Virus internalization was fully accomplished in less than 3 h but was then followed by a period of unprecedented length, about 14 h, until completion of nuclear import of the viral genome. Steps subsequent to virus entry depended on both intact microtubules and their dynamic turnover but not on actin cytoskeleton. Notably, cytoplasmic trafficking of viral particles and emergence of nuclear covalently closed circular DNA requires microtubules during entry only at and for specific time periods. Taken together, these data disclose for the first time a series of steps and their kinetics that are essential for the entry of hepatitis B viruses into hepatocytes and are different from those of any other virus reported so far.
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