ArticleJournal of virology2004
p53 targets simian virus 40 large T antigen for acetylation by CBP.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 64 citations in OpenAlex.
- Histone deacetylase III interactions with BK polyomavirus large tumor antigen may affect protein stability.Virology journal · 2023Article
- Contribution of DNA Replication to the FAM111A-Mediated Simian Virus 40 Host Range Phenotype.Journal of virology · 2019Article
- Review
- Phosphorylation of Merkel cell polyomavirus large tumor antigen at serine 816 by ATM kinase induces apoptosis in host cells.The Journal of biological chemistry · 2015Article
- Removal of a small C-terminal region of JCV and SV40 large T antigens has differential effects on transformation.Virology · 2014Article
- Merkel cell polyomavirus: molecular insights into the most recently discovered human tumour virus.Cancers · 2014Article
- Kruppel-like factor 15 is a critical regulator of cardiac lipid metabolism.The Journal of biological chemistry · 2014Article
- Two independent regions of simian virus 40 T antigen increase CBP/p300 levels, alter patterns of cellular histone acetylation, and immortalize primary cells.Journal of virology · 2013Article
- Merkel cell polyomavirus large T antigen has growth-promoting and inhibitory activities.Journal of virology · 2013Article
- Article
- Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus.The Journal of clinical investigation · 2012Article
- Article
- Review on the relationship between human polyomaviruses-associated tumors and host immune system.Clinical & developmental immunology · 2012Review
- Identification of FAM111A as an SV40 host range restriction and adenovirus helper factor.PLoS pathogens · 2012Article
- Article
- Epigenetic modulation of host: new insights into immune evasion by viruses.Journal of biosciences · 2010Review
- An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha.Molecular endocrinology (Baltimore, Md.) · 2010Article
- JC virus small T antigen binds phosphatase PP2A and Rb family proteins and is required for efficient viral DNA replication activity.PloS one · 2010Article
- GCN5-dependent acetylation of HIV-1 integrase enhances viral integration.Retrovirology · 2010Article
- KLF8 recruits the p300 and PCAF co-activators to its amino terminal activation domain to activate transcription.Cell cycle (Georgetown, Tex.) · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Simian virus 40 (SV40) large T antigen (T Ag) interacts with the tumor suppressor p53 and the transcriptional coactivators CBP and p300. Binding of these cellular proteins in a ternary complex has been implicated in T Ag-mediated transformation. It has been suggested that the ability of CBP/p300 to modulate p53 function underlies p53's regulation of cell proliferation and tumorigenesis. In this study, we provide further evidence that CBP activity may be mediated through its synergistic action with p53. We demonstrate that SV40 T Ag is acetylated in vivo in a p53-dependent manner and T Ag acetylation is largely mediated by CBP. The acetylation of T Ag is dependent on its interaction with p53 and on p53's interaction with CBP. We have mapped the site of acetylation on T Ag to the C-terminal lysine residue 697. This acetylation site is conserved between the T antigens of the human polyomaviruses JC and BK, which are also known to interact with p53. We show that both JC and BK T antigens are also acetylated at corresponding sites in vivo. While other proteins are known to be acetylated by CBP/p300, none are known to depend on p53 for acetylation. T Ag acetylation may provide a regulatory mechanism for T Ag binding to a cellular factor or play a role in another aspect of T Ag function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.