Trial reportHeart (British Cardiac Society)2004
Echocardiographic predictors of adverse clinical events in children with dilated cardiomyopathy: a prospective clinical study.
Trial report in Heart (British Cardiac Society), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Imaging based risk factors for heart failure death in childhood dilated cardiomyopathy: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- Predictors of disease progression in pediatric dilated cardiomyopathy.Circulation. Heart failure · 2013Trial
- Echocardiographic evaluation of children with systemic ventricular dysfunction treated with carvedilol.Pediatric cardiology · 2010Trial
- Baseline Predictors of Early Ventricular Recovery During Hospitalization in Children with Dilated Cardiomyopathy: A Short-Term Retrospective Study.Pediatric reports · 2026Article
- Multiparametric Assessment of TNNI3 Variant Phenotypes in Human iPSC-Cardiomyocytes Correlates with Disease Severity in Patients.bioRxiv : the preprint server for biology · 2025Article
- Screening left ventricular systolic dysfunction in children using intrinsic frequencies of carotid pressure waveforms measured by a novel smartphone-based device.Physiological measurement · 2023Article
- Exploring the Possible Impact of Echocardiographic Diastolic Function Parameters on Outcome in Paediatric Dilated Cardiomyopathy.Children (Basel, Switzerland) · 2022Article
- Peri-operative changes in diastolic function and outcomes in congenital aortic valve surgery.Echocardiography (Mount Kisco, N.Y.) · 2022Article
- Tissue Doppler, speckling tracking and four-dimensional echocardiographic assessment of right ventricular function in children with dilated cardiomyopathy.World journal of clinical pediatrics · 2022Article
- Anorexia nervosa-related cardiopathy in children with physical instability: prevalence, echocardiographic characteristics and reversibility at mid-term follow-up.European journal of pediatrics · 2021Article
- Parameters affecting outcome of paediatric cardiomyopathies in the intensive care unit: experience of an Egyptian tertiary centre over 7 years.The Libyan journal of medicine · 2020Article
- Left ventricular diastolic dysfunction in HIV-uninfected infants exposed in utero to antiretroviral therapy.AIDS (London, England) · 2020Article
- Prognostic significance of tissue Doppler imaging-derived myocardial performance index in pediatric patients with dilated cardiomyopathy.Pediatric transplantation · 2020Article
- Left Atrial Strain to Identify Diastolic Dysfunction in Children with Cardiomyopathies.Journal of clinical medicine · 2019Article
- Ventricular Arterial Coupling: A Novel Echocardiographic Risk Factor for Disease Progression in Pediatric Dilated Cardiomyopathy.Pediatric cardiology · 2019Article
- Forgotten Right Ventricle in Pediatric Dilated Cardiomyopathy.Pediatric cardiology · 2017Article
- Six-Minute Walk Test as a Predictor for Outcome in Children with Dilated Cardiomyopathy and Chronic Stable Heart Failure.Pediatric cardiology · 2017Article
- Impact of Interatrial Communication on Left Ventricle Performance in Patients with Significant Post-tricuspid Shunt.Pediatric cardiology · 2016Article
- Does surgically induced right bundle branch block really effect ventricular function in children after ventricular septal defect closure?Pediatric cardiology · 2015Article
- Left ventricular diastolic function in hypertension: methodological considerations and clinical implications.Journal of clinical medicine research · 2015Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo compare tissue Doppler (TD) velocities between patients with dilated cardiomyopathy (DCM) and normal controls and to determine whether TD velocities, Tei index, right ventricular fractional area change, and left ventricular ejection fraction (LVEF) predict adverse clinical outcomes in children with DCM.
methodsProspective evaluation of children with DCM.
results54 children with DCM and 54 age and sex matched control group participants were studied. Mitral inflow velocities were similar for both groups except for decreased mitral deceleration time in patients with DCM. Systolic and diastolic TD velocities at the mitral annulus (septal and lateral sides) and tricuspid annulus were significantly reduced in children with DCM compared with controls (p < 0.001 for each). By multivariate analysis, after adjustment for Tei index and right ventricular fractional area change, decreased LVEF and tricuspid velocity during early diastole (Ea) were predictors of the primary end point (PEP), a composite end point consisting of need for hospitalisation or the outcome transplantation or death. Tricuspid Ea velocity < 8.5 cm/s had 87% specificity and 60% sensitivity for reaching the PEP. LVEF < 30% had 68% specificity and 74% sensitivity for the PEP. Combined LVEF < 30% and tricuspid Ea < 11.5 cm/s had 100% specificity and 44% sensitivity for the PEP.
conclusionsChildren with DCM have significantly lower TD velocities than normal controls. In such cases, lower LVEF (< 30%) is more sensitive but less specific than lower tricuspid Ea velocities (< 8.5 cm/s) in predicting which patients are at risk of hospitalisation, transplantation, or death.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.