ReviewGlia2004
Glial modulation of synaptic transmission in the retina.
Review in Glia, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 131 citations in OpenAlex.
- Crosstalk Between Neuronal and Glial Cells in Diabetic Retinopathy: Mechanisms and Implications for Neurodegeneration.Molecular neurobiology · 2025Review
- ATP-mediated increase in HJournal of neurophysiology · 2024Article
- Thalamocortical circuits in generalized epilepsy: Pathophysiologic mechanisms and therapeutic targets.Neurobiology of disease · 2023Review
- P2XFEBS open bio · 2022Article
- Metabolic Imbalance Effect on Retinal Müller Glial Cells Reprogramming Capacity: Involvement of Histone Deacetylase SIRT6.Frontiers in genetics · 2021Article
- Dopamine-Evoked Synaptic Regulation in the Nucleus Accumbens Requires Astrocyte Activity.Neuron · 2020Article
- Implications of TORCH Diseases in Retinal Development-Special Focus on Congenital Toxoplasmosis.Frontiers in cellular and infection microbiology · 2020Review
- Adenosine receptor expression in the adult zebrafish retina.Purinergic signalling · 2019Article
- Purinergic signaling in the retina: From development to disease.Brain research bulletin · 2019Review
- Acute ethanol exposure has bidirectional actions on the endogenous neuromodulator adenosine in rat hippocampus.British journal of pharmacology · 2018Article
- Activation of retinal glial (Müller) cells by extracellular ATP induces pronounced increases in extracellular H+ flux.PloS one · 2018Article
- Article
- Reducing Extracellular CaFrontiers in neural circuits · 2017Article
- Signaling mechanism for modulation by ATP of glycine receptors on rat retinal ganglion cells.Scientific reports · 2016Article
- The role of glia in stress: polyamines and brain disorders.The Psychiatric clinics of North America · 2014Review
- Astrocytic adenosine: from synapses to psychiatric disorders.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Purinergic neuron-glia interactions in sensory systems.Pflugers Archiv : European journal of physiology · 2014Review
- Purines in the eye: recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal gland.Experimental eye research · 2014Review
- Adenosine modulates light responses of rat retinal ganglion cell photoreceptors througha cAMP-mediated pathway.The Journal of physiology · 2014Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Glial modulation of synaptic transmission and neuronal excitability in the mammalian retina is mediated by several mechanisms. Stimulation of glial cells evokes Ca(2+) waves, which propagate through the network of retinal astrocytes and Müller cells and result in the modulation of the activity of neighboring ganglion cells. Light-evoked spiking is enhanced in some ganglion cells and depressed in others. A facilitation or depression of light-evoked excitatory postsynaptic currents is also seen in ganglion cells following glial stimulation. In addition, stimulation of glial cells evokes a sustained hyperpolarizing current in ganglion cells which is mediated by ATP release from Müller cells and activation of neuronal A(1) adenosine receptors. Recent studies reveal that light-evoked activity in retinal neurons results in an increase in the frequency of Ca(2+) transients in Müller cells. Thus, there is two-way communication between neurons and glial cells, suggesting that glia contribute to information processing in the retina.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.