ArticleAmerican journal of human genetics2004
Genomewide scan for gout in taiwanese aborigines reveals linkage to chromosome 4q25.
Article in American journal of human genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Determinants of the prevalence of gout in the general population: a systematic review and meta-regression.European journal of epidemiology · 2015Pooled it
- Correlation analysis of serum TLR4 protein levels and TLR4 gene polymorphisms in gouty arthritis patients.PloS one · 2024Article
- Gain-of-function mutations inAnnals of the rheumatic diseases · 2022Article
- Systematic Review of the Role of Alpha-Protein Kinase 1 in Cancer and Cancer-Related Inflammatory Diseases.Cancers · 2022Review
- Ethnicity-based classifications and medical genetics: One Health approaches from a Western Pacific perspective.Frontiers in genetics · 2022Review
- Interaction of Alcohol Consumption andJournal of personalized medicine · 2021Article
- Physiology, Development, and Disease Modeling in theGenetics · 2020Review
- Impact of Early Life or Intrauterine Factors and Socio-Economic Interaction on Diabetes - An Evidence on Thrifty Hypothesis.Journal of lifestyle medicine · 2019Review
- Prevalence of hyperuricemia and its associated factors in the general Korean population: an analysis of a population-based nationally representative sample.Clinical rheumatology · 2018Article
- Epidermal growth factor gene is a newly identified candidate gene for gout.Scientific reports · 2016Article
- ALPK1 phosphorylates myosin IIA modulating TNF-α trafficking in gout flares.Scientific reports · 2016Article
- Article
- Functional polymorphisms of the ABCG2 gene are associated with gout disease in the Chinese Han male population.International journal of molecular sciences · 2014Article
- ALPK1 genetic regulation and risk in relation to gout.International journal of epidemiology · 2013Article
- Common dysfunctional variants in ABCG2 are a major cause of early-onset gout.Scientific reports · 2013Article
- Decreased extra-renal urate excretion is a common cause of hyperuricemia.Nature communications · 2012Article
- Lymphocyte α-kinase is a gout-susceptible gene involved in monosodium urate monohydrate-induced inflammatory responses.Journal of molecular medicine (Berlin, Germany) · 2011Article
- Gout in the Hmong in the United States.Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases · 2010Article
- Congenic strains displaying similar clinical phenotype of arthritis represent different immunologic models of inflammation.Genes and immunity · 2008Article
- New developments in the epidemiology and genetics of gout.Current rheumatology reports · 2006Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Gout is a disorder of uric-acid metabolism. The Pacific Austronesian population, including Taiwanese aborigines, has a remarkably high prevalence of hyperuricemia and gout, which suggests a founder effect across the Pacific region. We report here a genomewide linkage study of 21 multiplex pedigrees with gout from an aboriginal tribe in Taiwan. From observations of familial clustering, early onset of gout, and clinically severe manifestations, we hypothesized that a major gene plays a role in this trait. Using 382 random polymorphic markers spread across 22 autosomes, we demonstrated a highly significant linkage for gout at marker D4S2623 on chromosome 4q25 (P=.0002 by nonparametric linkage [the NPL(all) statistic]; empirical P=.0006; LOD=4.3, P=4.4x10-6 by logistic regression). When alcohol consumption was included as a covariate in the model, the LOD score increased to 5.66 (P=1.3x10-6). Quantitative traits, including serum uric acid and creatinine, also showed a moderate linkage to this region. To our knowledge, this is the first genome-scan report to identify a genetic locus harboring a gout-susceptibility gene.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.