ArticleNucleic acids research2004
ChIP Display: novel method for identification of genomic targets of transcription factors.
Article in Nucleic acids research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- DNA-protein interactions: methods for detection and analysis.Molecular and cellular biochemistry · 2012Review
- The current state of chromatin immunoprecipitation.Molecular biotechnology · 2010Review
- Repression of Runx2 by androgen receptor (AR) in osteoblasts and prostate cancer cells: AR binds Runx2 and abrogates its recruitment to DNA.Molecular endocrinology (Baltimore, Md.) · 2009Article
- Genomic location analysis by ChIP-Seq.Journal of cellular biochemistry · 2009Review
- Identification of novel androgen receptor target genes in prostate cancer.Molecular cancer · 2007Article
- Affinity selection of DNA-binding protein complexes using mRNA display.Nucleic acids research · 2006Article
- Distinct profiles of REST interactions with its target genes at different stages of neuronal development.Molecular biology of the cell · 2005Article
- Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors.The Journal of cell biology · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Novel protein-DNA interactions in mammalian cells are traditionally discovered in the course of promoter studies. The genomic era presents opportunities for the reverse; namely, the discovery of novel target genes for transcription factors of interest. Chromatin immunoprecipitation (ChIP) is typically used to test whether a protein binds to a candidate promoter in living cells. We developed a new method, ChIP Display (CD), which allows genome-wide unbiased identification of target genes occupied by transcription factors of interest. Initial CD experiments pursuing target genes for RUNX2, an osteoblast master transcription factor, have already resulted in the identification of four genes that had never been reported as targets of RUNX2. One of them, Osbpl8, was subjected to mRNA and promoter-reporter analyses, which provided functional proof for its regulation by RUNX2. CD will help to assemble the puzzle of interactions between transcription factors and the genome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.