ArticleMolecular genetics and genomics : MGG2004
The white-phase-specific gene WH11 is not required for white-opaque switching in Candida albicans.
Article in Molecular genetics and genomics : MGG, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- White-opaque switching inMicrobiology and molecular biology reviews : MMBR · 2024Review
- Candida albicans forms a specialized "sexual" as well as "pathogenic" biofilm.Eukaryotic cell · 2013Article
- White-opaque switching of Candida albicans allows immune evasion in an environment-dependent fashion.Eukaryotic cell · 2013Article
- Regulation of white-opaque switching in Candida albicans.Medical microbiology and immunology · 2010Review
- Environmental induction of white-opaque switching in Candida albicans.PLoS pathogens · 2008Article
- Current awareness on yeast.Yeast (Chichester, England) · 2005Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
Phenotypic switching between white and opaque cells is important for adaptation to different host environments and for mating in the opportunistic fungal pathogen Candida albicans. Genes that are specifically activated in one of the two cell types are likely to be important for their phenotypic characteristics. The WH11 gene is a white-phase-specific gene that has been suggested to be involved in the maintenance of the white-phase phenotype. To elucidate the role of WH11 in white-opaque switching, we constructed mutants of the C. albicans strain WO-1 in which the WH11 gene was deleted. The Delta wh11 mutants were still able to form both white and opaque cells whose cellular and colony phenotypes were indistinguishable from those of the wild type. Deletion of WH11 also did not affect the activation and deactivation of the white-phase-specific WH11 promoter and the opaque-phase-specific OP4 and SAP1 promoters in the appropriate cell type. Finally, switching from the white to the opaque phase and vice versa occurred with the same frequency in wild-type and Delta wh11 mutants. Therefore, the WH11 gene is not required for phenotypic switching, and its protein product seems to have other roles in white cells, which are dispensable after the switch to the opaque phase.
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