Trial reportMolecular psychiatry2004
A genome scan and follow-up study identify a bipolar disorder susceptibility locus on chromosome 1q42.
Trial report in Molecular psychiatry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 102 citations in OpenAlex.
- Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia.Molecular psychiatry · 2005Trial
- Cellular and proteomic differences associated with lithium response in olfactory neuroepithelium cells of bipolar disorder patients.Molecular medicine (Cambridge, Mass.) · 2025Article
- Overexpression of Truncated Human DISC1 Induces Appearance of Hindbrain Oligodendroglia in the Forebrain During Development.Schizophrenia bulletin · 2018Article
- Copy Number Variations in DISC1 and DISC1-Interacting Partners in Major Mental Illness.Molecular neuropsychiatry · 2015Article
- The cortical thickness phenotype of individuals with DISC1 translocation resembles schizophrenia.The Journal of clinical investigation · 2015Article
- Neuronal migration abnormalities and its possible implications for schizophrenia.Frontiers in neuroscience · 2015Review
- Role of disrupted in schizophrenia 1 (DISC1) in stress-induced prefrontal cognitive dysfunction.Translational psychiatry · 2013Article
- DISC1 as a therapeutic target for mental illnesses.Expert opinion on therapeutic targets · 2012Review
- Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms.Molecular psychiatry · 2012Article
- Comprehensive behavioral analysis of ENU-induced Disc1-Q31L and -L100P mutant mice.BMC research notes · 2012Article
- Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes.Molecular psychiatry · 2011Article
- DISC1 regulates synaptic vesicle transport via a lithium-sensitive pathway.Neuroscience research · 2011Article
- Expression of mutant human DISC1 in mice supports abnormalities in differentiation of oligodendrocytes.Schizophrenia research · 2011Article
- Convergent functional genomic studies of ω-3 fatty acids in stress reactivity, bipolar disorder and alcoholism.Translational psychiatry · 2011Article
- Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia.Neuroscience and biobehavioral reviews · 2011Review
- Article
- Genetics and intermediate phenotypes of the schizophrenia--bipolar disorder boundary.Neuroscience and biobehavioral reviews · 2010Review
- A genome-wide linkage study of bipolar disorder and co-morbid migraine: replication of migraine linkage on chromosome 4q24, and suggestion of an overlapping susceptibility region for both disorders on chromosome 20p11.Journal of affective disorders · 2010Article
- Translin-associated factor X gene (TSNAX) may be associated with female major depressive disorder in the Japanese population.Neuromolecular medicine · 2010Article
- DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we report a genome scan for psychiatric disease susceptibility loci in 13 Scottish families. We follow up one of the linkage peaks on chromosome 1q in a substantially larger sample of 22 families affected by schizophrenia (SCZ) or bipolar affective disorder (BPAD). To minimise the effect of genetic heterogeneity, we collected mainly large extended families (average family size >18). The families collected were Scottish, carried no chromosomal abnormalities and were unrelated to the large family previously reported as segregating a balanced (1:11) translocation with major psychiatric disease. In the genome scan, we found linkage peaks with logarithm of odds (LOD) scores >1.5 on chromosomes 1q (BPAD), 3p (SCZ), 8p (SCZ), 8q (BPAD), 9q (BPAD) and 19q (SCZ). In the follow-up sample, we obtained most evidence for linkage to 1q42 in bipolar families, with a maximum (parametric) LOD of 2.63 at D1S103. Multipoint variance components linkage gave a maximum LOD of 2.77 (overall maximum LOD 2.47 after correction for multiple tests), 12 cM from the previously identified SCZ susceptibility locus DISC1. Interestingly, there was negligible evidence for linkage to 1q42 in the SCZ families. These results, together with results from a number of other recent studies, stress the importance of the 1q42 region in susceptibility to both BPAD and SCZ.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.