ArticleProceedings of the National Academy of Sciences of the United States of America2004
Development of a cancer DNA phenotype prior to tumor formation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 61 citations in OpenAlex.
- Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy.Cancer research · 2021Article
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- Nonmuscle myosin IIA and IIB differentially modulate migration and alter gene expression in primary mouse tumorigenic cells.Molecular biology of the cell · 2019Article
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- Label-Free Raman Spectroscopy Detects Stromal Adaptations in Premetastatic Lungs Primed by Breast Cancer.Cancer research · 2017Article
- A label-free approach by infrared spectroscopic imaging for interrogating the biochemistry of diabetic nephropathy progression.Kidney international · 2016Article
- Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?Carcinogenesis · 2015Review
- Infrared microspectroscopy identifies biomolecular changes associated with chronic oxidative stress in mammary epithelium and stroma of breast tissues from healthy young women: implications for latent stages of breast carcinogenesis.Cancer biology & therapy · 2014Article
- Pronounced cancer resistance in a subterranean rodent, the blind mole-rat, Spalax: in vivo and in vitro evidence.BMC biology · 2013Article
- Destructive impact of T-lymphocytes, NK and Mast cells on basal cell layers: implications for tumor invasion.BMC cancer · 2013Article
- Tumor-infiltrating immune cells promoting tumor invasion and metastasis: existing theories.Journal of Cancer · 2013Article
- Fourier transform infrared microspectroscopy as a diagnostic tool for distinguishing between normal and malignant human gastric tissue.Journal of biosciences · 2011Article
- Malignant transformation and stromal invasion from normal or hyperplastic tissues: true or false?Journal of Cancer · 2011Article
- Increased invasiveness and aggressiveness in breast epithelia with cytoplasmic p63 expression.International journal of biological sciences · 2010Article
- A seemingly most effective target for early detection and intervention of prostate tumor invasion.Journal of Cancer · 2010Article
- Administration of cyclophosphamide changes the immune profile of tumor-bearing mice.Journal of immunotherapy (Hagerstown, Md. : 1997) · 2010Article
- Correlated alterations in prostate basal cell layer and basement membrane.International journal of biological sciences · 2009Article
- Aberrant p63 and WT-1 expression in myoepithelial cells of pregnancy-associated breast cancer: implications for tumor aggressiveness and invasiveness.International journal of biological sciences · 2009Article
- Aberrant c-erbB2 expression in cell clusters overlying focally disrupted breast myoepithelial cell layers: a trigger or sign for emergence of more aggressive cell clones?International journal of biological sciences · 2008Article
- Bad seeds produce bad crops: a single stage-process of prostate tumor invasion.International journal of biological sciences · 2008Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Using the carcinogen 3-methylcholanthrene (MCA), we demonstrate with Fourier transform-infrared spectroscopy that a cancer DNA phenotype is produced well in advance of palpable tumors. We further demonstrate that the administration of cyclophosphamide markedly inhibits the development of the cancer phenotype and concomitantly delays tumor formation. MCA, injected into the hind legs of mice, produced a variety of significant structural changes in the nucleotide bases and phosphodiester-deoxyribose backbone, as reflected in a substantial (34%) difference between the mean DNA spectra of the control and the MCA-injected mice. Strikingly, 57 days before the mean appearance of tumors, we could not distinguish the DNA structure of the histologically normal tissues of the MCA-injected mice from the DNA structure of the tumor tissues. This finding indicates the early development of a cancer phenotype. Confirmatory evidence was obtained when tissues from a group of mice injected with both MCA and cyclophosphamide did not manifest the cancer phenotype, and their mean DNA structure closely resembled that of the control mice. Accordingly, we propose that the cancer DNA phenotype, as evinced by Fourier transform-infrared spectroscopy, is a promising early indicator of tumor formation, and we postulate that agents capable of inhibiting this phenotype may delay or prevent carcinogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.