ArticleThe Journal of cell biology2004
A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast.
Article in The Journal of cell biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 84 citations in OpenAlex.
- Arg1 frommBio · 2024Article
- Regulation of phosphoinositide metabolism in Apicomplexan parasites.Frontiers in cell and developmental biology · 2023Review
- PIP kinases: A versatile family that demands further therapeutic attention.Advances in biological regulation · 2023Article
- HJournal of fungi (Basel, Switzerland) · 2021Article
- Inhibiting fusion with cellular membrane system: therapeutic options to prevent severe acute respiratory syndrome coronavirus-2 infection.American journal of physiology. Cell physiology · 2020Review
- A synthetic biological approach to reconstitution of inositide signaling pathways in bacteria.Advances in biological regulation · 2019Article
- The P5A ATPase Spf1p is stimulated by phosphatidylinositol 4-phosphate and influences cellular sterol homeostasis.Molecular biology of the cell · 2019Article
- Deletion ofJournal of fungi (Basel, Switzerland) · 2018Article
- Analysis of the contribution of phosphoinositides to medial septation in fission yeast highlights the importance of PI(4,5)PMolecular biology of the cell · 2018Article
- Release of condensin from mitotic chromosomes requires the Ran-GTP gradient in the reorganized nucleus.Biology open · 2017Article
- How PI3K-derived lipids control cell division.Frontiers in cell and developmental biology · 2015Review
- A Pil1-Sle1-Syj1-Tax4 functional pathway links eisosomes with PI(4,5)P2 regulation.Journal of cell science · 2014Article
- Two distinct functions for PI3-kinases in macropinocytosis.Journal of cell science · 2013Article
- Characterization of Mid1 domains for targeting and scaffolding in fission yeast cytokinesis.Journal of cell science · 2012Article
- Article
- Molecular networks linked by Moesin drive remodeling of the cell cortex during mitosis.The Journal of cell biology · 2011Article
- Phosphatidylserine is polarized and required for proper Cdc42 localization and for development of cell polarity.Nature cell biology · 2011Article
- Phosphatidylinositol 3-phosphate, an essential lipid in Plasmodium, localizes to the food vacuole membrane and the apicoplast.Eukaryotic cell · 2010Article
- Role of septins in the orientation of forespore membrane extension during sporulation in fission yeast.Molecular and cellular biology · 2010Article
- Cytolethal distending toxin from Aggregatibacter actinomycetemcomitans induces DNA damage, S/G2 cell cycle arrest, and caspase- independent death in a Saccharomyces cerevisiae model.Infection and immunity · 2010Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
The mammalian tumor suppressor, phosphatase and tensin homologue deleted on chromosome 10 (PTEN), inhibits cell growth and survival by dephosphorylating phosphatidylinositol-(3,4,5)-trisphosphate (PI[3,4,5]P3). We have found a homologue of PTEN in the fission yeast, Schizosaccharomyces pombe (ptn1). This was an unexpected finding because yeast (S. pombe and Saccharomyces cerevisiae) lack the class I phosphoinositide 3-kinases that generate PI(3,4,5)P3 in higher eukaryotes. Indeed, PI(3,4,5)P3 has not been detected in yeast. Surprisingly, upon deletion of ptn1 in S. pombe, PI(3,4,5)P3 became detectable at levels comparable to those in mammalian cells, indicating that a pathway exists for synthesis of this lipid and that the S. pombe ptn1, like mammalian PTEN, suppresses PI(3,4,5)P3 levels. By examining various mutants, we show that synthesis of PI(3,4,5)P3 in S. pombe requires the class III phosphoinositide 3-kinase, vps34p, and the phosphatidylinositol-4-phosphate 5-kinase, its3p, but does not require the phosphatidylinositol-3-phosphate 5-kinase, fab1p. These studies suggest that a pathway for PI(3,4,5)P3 synthesis downstream of a class III phosphoinositide 3-kinase evolved before the appearance of class I phosphoinositide 3-kinases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.