ArticleAmerican journal of human genetics2004
Evidence for a novel late-onset Alzheimer disease locus on chromosome 19p13.2.
Article in American journal of human genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
45 citing papers in PubMed.
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- Peptidyl-ProlylFrontiers in cell and developmental biology · 2020Review
- Genome-wide linkage analyses of non-Hispanic white families identify novel loci for familial late-onset Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2016Article
- AlzBase: an Integrative Database for Gene Dysregulation in Alzheimer's Disease.Molecular neurobiology · 2016Article
- Family-based genome scan for age at onset of late-onset Alzheimer's disease in whole exome sequencing data.Genes, brain, and behavior · 2015Article
- Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy.Nature · 2015Article
- DNA methyltransferase 1 mutations and mitochondrial pathology: is mtDNA methylated?Frontiers in genetics · 2015Article
- Alzheimer's disease--a panorama glimpse.International journal of molecular sciences · 2014Review
- Joint linkage and association analysis with exome sequence data implicates SLC25A40 in hypertriglyceridemia.American journal of human genetics · 2013Article
- Genome scan in familial late-onset Alzheimer's disease: a locus on chromosome 6 contributes to age-at-onset.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2013Article
- DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss.Neurology · 2013Article
- A PIN1 polymorphism that prevents its suppression by AP4 associates with delayed onset of Alzheimer's disease.Neurobiology of aging · 2012Article
- Association study of candidate gene polymorphisms with amnestic mild cognitive impairment in a Chinese population.PloS one · 2012Article
- Genome-wide DNA methylation differences between late-onset Alzheimer's disease and cognitively normal controls in human frontal cortex.Journal of Alzheimer's disease : JAD · 2012Article
- Genome scan of age-at-onset in the NIMH Alzheimer disease sample uncovers multiple loci, along with evidence of both genetic and sample heterogeneity.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2011Article
- Panel of Genetic Variations as a Potential Non-invasive Biomarker for Early Diagnosis of Alzheimer's Disease.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2011Article
- Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss.Nature genetics · 2011Article
- Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.PLoS genetics · 2011Article
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Authors and funding
9 authors.
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Abstract
Late-onset familial Alzheimer disease (LOFAD) is a genetically heterogeneous and complex disease for which only one locus, APOE, has been definitively identified. Difficulties in identifying additional loci are likely to stem from inadequate linkage analysis methods. Nonparametric methods suffer from low power because of limited use of the data, and traditional parametric methods suffer from limitations in the complexity of the genetic model that can be feasibly used in analysis. Alternative methods that have recently been developed include Bayesian Markov chain-Monte Carlo methods. These methods allow multipoint linkage analysis under oligogenic trait models in pedigrees of arbitrary size; at the same time, they allow for inclusion of covariates in the analysis. We applied this approach to an analysis of LOFAD on five chromosomes with previous reports of linkage. We identified strong evidence of a second LOFAD gene on chromosome 19p13.2, which is distinct from APOE on 19q. We also obtained weak evidence of linkage to chromosome 10 at the same location as a previous report of linkage but found no evidence for linkage of LOFAD age-at-onset loci to chromosomes 9, 12, or 21.
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