ArticlePsychopharmacology2004
Genetic features of antidepressant induced mania and hypo-mania in bipolar disorder.
Article in Psychopharmacology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Efficacy of pharmacotherapy in bipolar disorder: a report by the WPA section on pharmacopsychiatry.European archives of psychiatry and clinical neuroscience · 2012Pooled it
- Population-based and family-based studies on the serotonin transporter gene polymorphisms and bipolar disorder: a systematic review and meta-analysis.Molecular psychiatry · 2005Pooled it
- Antidepressant-Associated Treatment Emergent Mania: A Meta-Analysis to Guide Risk Modeling Pharmacogenomic Targets of Potential Clinical Value.Journal of clinical psychopharmacologyPooled it
- Mood regulation in euthymic patients with a history of antidepressant-induced mania.Bipolar disorders · 2024Article
- The Role of Pharmacogenetics in Personalizing the Antidepressant and Anxiolytic Therapy.Genes · 2023Review
- Nursing students and depressive symptomatology: an observational study in University of Palermo.Mental illness · 2019Article
- Dosage-related nature of escitalopram treatment-emergent mania/hypomania: a case series.Neuropsychiatric disease and treatment · 2018Article
- A neurobiological hypothesis of treatment-resistant depression - mechanisms for selective serotonin reuptake inhibitor non-efficacy.Frontiers in behavioral neuroscience · 2014Review
- Course of illness following prospectively observed mania or hypomania in individuals presenting with unipolar depression.Bipolar disorders · 2012Article
- Pharmacogenetics of antidepressant drugs: current clinical practice and future directions.Pharmacogenomics · 2012Review
- Association of the 5-HTT gene-linked promoter region (5-HTTLPR) polymorphism with psychiatric disorders: review of psychopathology and pharmacotherapy.Pharmacogenomics and personalized medicine · 2012Article
- Pharmacogenetics of antidepressant response.Journal of psychiatry & neuroscience : JPN · 2011Review
- Pharmacogenetics of antidepressants.Frontiers in pharmacology · 2011Article
- The neurobiology of the switch process in bipolar disorder: a review.The Journal of clinical psychiatry · 2010Review
- Pharmacogenetics in mood disorder.Current opinion in psychiatry · 2005Article
- Genetics and psychopharmacology: prospects for individualized treatment.Essential psychopharmacology · 2005Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RATIONALE AND
objectivesThe present study investigated possible genetic association between some polymorphisms possibly involved in antidepressant response and the occurrence of manic or hypo-manic switches during antidepressant treatment.
methodsWe retrospectively examined 169 individuals with a diagnosis of bipolar disorder (BP) type I ( n=103) and II ( n=66), who presented at least one sudden manic or hypo-manic episode (according to DSM IV criteria) during antidepressant therapy, that occurred within a period of 3 weeks from the beginning of the treatment and without any interposed period of well being ("manic switch"). They were compared with a sex, age, and ethnicity-matched group of 247 subjects, randomly selected from our pool of bipolar subjects, who never showed switches. We then randomly selected from the whole sample ("switched" and "not switched") a sub-sample of patients not under mood stabiliser treatment at the time of the index episode (65 "switched" and 117 "not switched") and compared them with a sex, age and ethnicity matched group of 133 subjects, randomly selected from our pool of major depressed patients, who did not present manic switches. The functional polymorphism in the upstream regulatory region of the serotonin transporter (SERTPR), tryptophan hydroxylase (TPH), G-protein beta 3 subunit (Gbeta3), monoamine oxidase A (MAO-A), catechol- O-methyltransferase (COMT), serotonin receptor 2A (5-HT2A), dopamine receptor D2 (DRD2) and dopamine receptor D4 (DRD4) gene variants were analysed using PCR-based techniques. RESULTS AND
conclusionsThe distribution of the genetic polymorphisms was not significantly different between switched and not-switched patients ( P>0.006-Bonferroni corrected). Moreover, no significant difference was found between switched and not switched sub-samples and the sample of major depressed subjects. Further studies are required to investigate other possible related genetic variants influencing the timing of manic-depressive cycle.
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Registered trials
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