ArticleNature neuroscience2004
Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate.
Article in Nature neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 79 citations in OpenAlex.
- Ancient Somatosensory Circuit Architectures Employ Flexible Molecular Strategies.bioRxiv : the preprint server for biology · 2026Article
- Temporal refinement of Dach1 expression contributes to the development of somatosensory neurons.The EMBO journal · 2025Article
- Novel mutations in UMolecular therapy. Methods & clinical development · 2023Article
- Influencers in the Somatosensory System: Extrinsic Control of Sensory Neuron Phenotypes.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2023Review
- Dominant aminoacyl-tRNA synthetase disorders: lessons learned fromFrontiers in neuroscience · 2023Review
- Nobel somatosensations and pain.Pflugers Archiv : European journal of physiology · 2022Review
- Identification of Neuronal Cells in Sciatic Nerves of Adult Rats.Frontiers in cellular neuroscience · 2022Article
- Review
- Early Life Nociception is Influenced by Peripheral Growth Hormone Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation.Cell reports · 2021Article
- Long-distance regressive signaling in neural development and disease.Wiley interdisciplinary reviews. Developmental biology · 2021Review
- The development of somatosensory neurons: Insights into pain and itch.Current topics in developmental biology · 2021Review
- Local injections of β-NGF accelerates endochondral fracture repair by promoting cartilage to bone conversion.Scientific reports · 2020Article
- Fracture repair requires TrkA signaling by skeletal sensory nerves.The Journal of clinical investigation · 2019Article
- Cav3.2 T-type calcium channels shape electrical firing in mouse Lamina II neurons.Scientific reports · 2019Article
- Trk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused byProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Genetic ablation of GINIP-expressing primary sensory neurons strongly impairs Formalin-evoked pain.Scientific reports · 2017Article
- NGF-TrkA Signaling by Sensory Nerves Coordinates the Vascularization and Ossification of Developing Endochondral Bone.Cell reports · 2016Article
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Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
Tactile information is perceived by a heterogeneous population of specialized neurons. Neurotrophin receptors (the receptor tyrosine kinases, Trks) mark the major classes of these sensory neurons: TrkA is expressed in neurons that sense temperature and noxious stimuli, and TrkC is expressed in proprioceptive neurons that sense body position. Neurotrophin signaling through these receptors is required for cell survival. To test whether neurotrophins have an instructive role in sensory specification, we expressed rat TrkC from the TrkA (also known as Ntrk1) locus in mice. The surviving presumptive TrkA-expressing neurons adopted a proprioceptive phenotype, indicating that neurotrophin signaling can specify sensory neuron subtypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.