Evidence map›Paper›PMID 15247496›Full record

ReviewMolecular biotechnology2004

Biomedical and agricultural applications of animal transgenesis.

Alison J Thomson, Jim McWhir

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biotechnology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alison J ThomsonDepartment of Gene Expression and Development, Roslin Institute, Roslin, Midlothian, UK. Alison.Thomson@bbsrc.ac.uk
Jim McWhir

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Additive transgenesis by pronuclear injection of the mouse zygote has been in use for more than 20 yr and gene targeting in mouse embryonic stem cells for almost as long. Together, these techniques have revolutionized animal biology by helping to unravel much of what we now know about gene function. Both additive transgenics and targeting can also be performed in livestock species but the impact has not yet been substantial. In part, this has been the result of the inefficiency of the techniques but-at least in agriculture-also to a lack of obvious practicality. This review assesses the extent to which this situation is changing, with particular reference to applications in biopharming, xenotransplantation, and large animal models.

Indexed as

Animals, Genetically ModifiedAgricultureAnimalsAnimals, DomesticBiomedical EngineeringBiopharmaceuticsDisease Models, AnimalGenetic EngineeringGenetic TherapyHumansTransplantation, Heterologous

Identifiers

PMID15247496

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.