ReviewMolecular neurobiology2004
Neural stem cells redefined: a FACS perspective.
Review in Molecular neurobiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 37 citations in OpenAlex.
- Protective roles of melatonin in central nervous system diseases by regulation of neural stem cells.Cell proliferation · 2017Review
- A non-aggressive, highly efficient, enzymatic method for dissociation of human brain-tumors and brain-tissues to viable single-cells.BMC neuroscience · 2016Article
- Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers.Molecular and cellular endocrinology · 2011Article
- Murine cytomegalovirus infection of neural stem cells alters neurogenesis in the developing brain.PloS one · 2011Article
- Phosphorylation of p27Kip1 at Thr187 by cyclin-dependent kinase 5 modulates neural stem cell differentiation.Molecular biology of the cell · 2010Article
- CD15, CD24, and CD29 define a surface biomarker code for neural lineage differentiation of stem cells.Stem cells (Dayton, Ohio) · 2009Article
- In vivo labeling of adult neural progenitors for MRI with micron sized particles of iron oxide: quantification of labeled cell phenotype.NeuroImage · 2009Article
- Self-renewing and differentiating properties of cortical neural stem cells are selectively regulated by basic fibroblast growth factor (FGF) signaling via specific FGF receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Simian fetal brain progenitor cells for studying viral neuropathogenesis.Journal of neurovirology · 2007Article
- Identification of a novel oligodendrocyte cell adhesion protein using gene expression profiling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Molecular and morphological heterogeneity of neural precursors in the mouse neocortical proliferative zones.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Challenges in the study of neuronal differentiation: a view from the embryonic eye.Developmental dynamics : an official publication of the American Association of Anatomists · 2005Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Using the generally accepted ontogenetic definition, neural stem cells (NSCs) are characterized as undifferentiated cells originating from the neuroectoderm that have the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors (LRP). LRPs can themselves undergo limited self-renewal, then ultimately differentiate into highly specialized cells that compose the nervous system. However, this physiologically delimited definition of NSCs has been increasingly blurred in the current state of the field, as the great majority of studies have retrospectively inferred the existence of NSCs based on their deferred functional capability rather than prospectively identifying the actual cells that created the outcome. Further complicating the matter is the use of a wide variety of neuroepithelial or neurosphere preparations as a source of putative NSCs, without due consideration that these preparations are themselves composed of heterogeneous populations of both NSCs and LRPs. This article focuses on recent attempts using FACS strategies to prospectively isolate NSCs from different types of LRPs as they appear in vivo and reveals the contrasting differences among these populations at molecular, phenotypic, and functional levels. Thus, the strategies presented here provide a framework for more precise studies of NSC and LRP cell biology in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.