ArticleGut2004
Effect of Th1 cytokines on acid secretion in pharmacologically characterised mouse gastric glands.
Article in Gut, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 34 citations in OpenAlex.
- Roles of interleukins in spasmolytic polypeptide‑expressing metaplasia (Review).International journal of oncology · 2026Review
- Malaria parasite infection compromises colonization resistance to an enteric pathogen by reducing gastric acidity.Science advances · 2021Article
- The Physiology of the Gastric Parietal Cell.Physiological reviews · 2020Review
- Genetic determinants and clinico-pathological outcomes of helicobacter pylori infection.Annals of Ibadan postgraduate medicine · 2014Review
- Sonic hedgehog mediates the proliferation and recruitment of transformed mesenchymal stem cells to the stomach.PloS one · 2013Article
- Spontaneous autoimmune gastritis and hypochlorhydria are manifest in the ileitis-prone SAMP1/YitFcs mice.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- Helicobacter pylori infection and cytokine gene polymorphisms in Uzbeks.Nagoya journal of medical science · 2010Article
- Influence of interleukin polymorphisms on development of gastric cancer and peptic ulcer.World journal of gastroenterology · 2010Review
- Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population.Japanese journal of clinical oncology · 2008Article
- Accelerated progression of gastritis to dysplasia in the pyloric antrum of TFF2 -/- C57BL6 x Sv129 Helicobacter pylori-infected mice.The American journal of pathology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsAcid secretion plays an important role in the ecology of Helicobacter species and acid secretory status heralds patterns of gastritis. The presence of inflammatory cells and their products, in close proximity to parietal cells, questions the extent of the effect of cytokines on acid secretion.
methodsWe adopted and extensively characterised the mouse gastric gland preparation and its secretory capacity, which was measured using (14)C-aminopyrine accumulation. Subsequently, we tested the secretory properties of a wide range of species specific cytokines, including those associated with Th1 and Th2 immune responses.
results(14)C-aminopyrine accumulation in mouse gastric glands was shown to be a very sensitive "in vitro" method of testing classical secretagogues and antisecretory compounds, and provided pharmacological data on acid secretion in the mouse. Only two mouse cytokines, interleukin 2 and interferon gamma, had a direct effect on acid secretion causing dose dependent inhibition.
conclusionsBoth cytokines belong to the Th1 type immune response and consequently their inhibitory effect may play a role in the hyposecretion seen with H pylori infection and colonisation throughout the corpus of the stomach that potentially can lead to gastric atrophy and subsequently, in some cases, cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.