ArticleDiabetologia2004
Non-esterified fatty acids impair insulin-mediated glucose uptake and disposition in the liver.
Article in Diabetologia, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 46 citations in OpenAlex.
- Effects of short-term sprint interval and moderate-intensity continuous training on liver fat content, lipoprotein profile, and substrate uptake: a randomized trial.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Trial
- Estimates of insulin sensitivity from the intravenous-glucose-modified-clamp test depend on suppression of lipolysis in type 2 diabetes: a randomised controlled trial.Diabetologia · 2014Trial
- Sleep disordered breathing and circulating non-esterified fatty acids: the cardiovascular health study.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Advances and challenges in measuring hepatic glucose uptake with FDG PET: implications for diabetes research.Diabetologia · 2024Review
- The Associations of Individual and Subclasses of Nonesterified Fatty Acids With Disability, and Mobility Limitation in Older Adults: The Cardiovascular Health Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Non-esterified fatty acids and risk of peripheral artery disease in older adults: The cardiovascular health study.Atherosclerosis · 2023Article
- Nonesterified Fatty Acids and Hospitalizations Among Older Adults: The Cardiovascular Health Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Non-Esterified Fatty Acids and Risks of Frailty, Disability, and Mobility Limitation in Older Adults: The Cardiovascular Health Study.Journal of the American Geriatrics Society · 2020Article
- Non-esterified fatty acids and telomere length in older adults: The Cardiovascular Health Study.Metabolism open · 2020Article
- The kinetics ofEJNMMI research · 2018Article
- Insulin-stimulated glucose uptake in skeletal muscle, adipose tissue and liver: a positron emission tomography study.European journal of endocrinology · 2018Article
- Hepato-splenic axis: hepatic and splenic metabolic activities are linked.American journal of nuclear medicine and molecular imaging · 2018Article
- Liver fat: a relevant target for dietary intervention? Summary of a Unilever workshop.Journal of nutritional science · 2017Review
- Comment on: Stefanovski et al. Estimating hepatic glucokinase activity using a simple model of lactate kinetics. Diabetes Care 2012;35:1015-1020.Diabetes care · 2012Article
- Liver fat content in type 2 diabetes: relationship with hepatic perfusion and substrate metabolism.Diabetes · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisWe investigated the effect of elevated circulating NEFA on insulin-mediated hepatic glucose uptake (HGU) and whole-body glucose disposal (M) in eight healthy male subjects.
methodsStudies were performed using positron emission tomography (PET) and [(18)F]-2-fluoro-2-deoxyglucose ([(18)F]FDG) during euglycaemic hyperinsulinaemia (0-120 min) and an Intralipid/heparin infusion (IL/Hep; -90-120 min). On a different day, similar measurements were taken during euglycaemic hyperinsulinaemia and saline infusion (SAL). Graphical and compartmental analyses were used to model liver data.
resultsCirculating NEFA increased approximately three-fold during IL/Hep, and declined by 81+/-7% in the SAL study ( p</=0.01). Both M (-28+/-7%) and HGU (-25+/-9%) were significantly lowered by NEFA elevation ( p=0.004 and p=0.035 respectively). In the whole data set, the decreases in M and HGU were positively correlated ( r=0.78, p=0.038). No evidence of [(18)F]FDG outflow was detected during the scanning time. HGU was correlated with the phosphorylation rate parameter ( r=0.71, p=0.003) as derived by compartmental modelling. CONCLUSIONS/
interpretationIn healthy men, NEFA impair insulin-mediated HGU and whole-body glucose uptake to a similar extent. Our data suggest that multiple intracellular NEFA targets may concur to down-regulate glucose uptake by the liver.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.