ArticleJournal of biomolecular NMR2004
Experiments for correlating quaternary carbons in RNA bases.
Article in Journal of biomolecular NMR, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Relaxation Optimized Heteronuclear Experiments for Extending the Size Limit of RNA Nuclear Magnetic Resonance.Journal of the American Chemical Society · 2025Article
- Characterization of the Deamination Coupled with Sliding along DNA of Anti-HIV Factor APOBEC3G on the Basis of the pH-Dependence of Deamination Revealed by Real-Time NMR Monitoring.Frontiers in microbiology · 2016Article
- Loss of loop adenines alters human telomere d[AG3(TTAG3)3] quadruplex folding.Nucleic acids research · 2014Article
- Nucleotide-type chemical shift assignment of the encapsulated 40 kbp dsDNA in intact bacteriophage T7 by MAS solid-state NMR.Journal of biomolecular NMR · 2014Article
- Structural determinants for ligand capture by a class II preQ1 riboswitch.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- HNHC: a triple resonance experiment for correlating the H2, N1(N3) and C2 resonances in adenine nucleobases of 13C-, 15N-labeled RNA oligonucleotides.Journal of biomolecular NMR · 2009Article
- Measurement of imino 1H-1H residual dipolar couplings in RNA.Journal of biomolecular NMR · 2009Article
- Effect of local sugar and base geometry on 13C and 15N magnetic shielding anisotropy in DNA nucleosides.Journal of biomolecular NMR · 2008Article
- 13C-detected NMR experiments for measuring chemical shifts and coupling constants in nucleic acid bases.Journal of biomolecular NMR · 2007Article
- Quantitative gamma-HCNCH: determination of the glycosidic torsion angle chi in RNA oligonucleotides from the analysis of CH dipolar cross-correlated relaxation by solution NMR spectroscopy.Journal of biomolecular NMR · 2007Article
- Structure and thermodynamics of a conserved U2 snRNA domain from yeast and human.RNA (New York, N.Y.) · 2007Article
- Dissecting non-canonical interactions in frameshift-stimulating mRNA pseudoknots.Journal of biomolecular NMR · 2006Article
- Measurement of long-range 1H-19F scalar coupling constants and their glycosidic torsion dependence in 5-fluoropyrimidine-substituted RNA.Journal of the American Chemical Society · 2006Article
- Resolution-enhanced base-type-edited HCN experiment for RNA.Journal of biomolecular NMR · 2005Article
- Iron responsive element RNA flexibility described by NMR and isotropic reorientational eigenmode dynamics.Journal of biomolecular NMR · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The paper presents a set of triple-resonance two-dimensional experiments for correlating all quaternary carbons in RNA bases to one or more of the base protons. The experiments make use of either three-bond proton-carbon couplings and one selective INEPT step (the long-range selective HSQC experiment) to transfer the magnetization between a proton and the carbon of interest and back, or they rely on one- and/or two-bond heteronuclear (the H(CN)C and H(N)C experiments) or carbon-carbon (the H(C)C experiment) couplings and multiple INEPT transfer steps. The effect of the large one-bond carbon-carbon coupling in t(1) is removed by a constant time evolution or by a selective refocusing. The performance of the proposed approach is demonstrated on a 0.5 mM 25-mer RNA. The results show that the experiments are applicable to samples containing agents for weak molecular alignment. The design of the correlation experiments has been supported by ab initio calculations of scalar spin-spin couplings in the free bases and the AU and GC base pairs. The ab initio data reveal surprisingly high values of guanine (2)J(N1C5) and uracil (2)J(N3C5) couplings that are in a qualitative agreement with the experimental data. The sensitivity of the spin-spin couplings to base pairing as well as the agreement with the experiment depend strongly on the type of nuclei involved and the number of bonds separating them.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.