ArticleProceedings of the National Academy of Sciences of the United States of America2004
Origins of recently gained introns in Caenorhabditis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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57 citing papers in PubMed, 130 citations in OpenAlex.
- Pervasive Conservation of Intron Number and Other Genetic Elements Revealed by a Chromosome-level Genome Assembly of the Hyper-polymorphic Nematode Caenorhabditis brenneri.Genome biology and evolution · 2025Article
- Pervasive conservation of intron number and other genetic elements revealed by a chromosome-level genomic assembly of the hyper-polymorphic nematodebioRxiv : the preprint server for biology · 2024Article
- Intron losses and gains in the nematodes.Biology direct · 2022Article
- Review
- Insights Into the Molecular Evolution of AT-Hook Motif Nuclear Localization Genes inFrontiers in plant science · 2021Article
- Hsp27 gene in Drosophila ananassae subgroup was split by a recently acquired intron.Journal of genetics · 2016Article
- Intron evolution in Saccharomycetaceae.Genome biology and evolution · 2014Article
- A novel model for development, organization, and function of gonadotropes in fish pituitary.Frontiers in endocrinology · 2014Article
- At the origin of spliceosomal introns: Is multiplication of introner-like elements the main mechanism of intron gain in fungi?Communicative & integrative biology · 2013Article
- Article
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- Microhomology-mediated intron loss during metazoan evolution.Genome biology and evolution · 2013Article
- Rather than by direct acquisition via lateral gene transfer, GHF5 cellulases were passed on from early Pratylenchidae to root-knot and cyst nematodes.BMC evolutionary biology · 2012Article
- Identifying the mechanisms of intron gain: progress and trends.Biology direct · 2012Review
- Origin and evolution of spliceosomal introns.Biology direct · 2012Review
- Article
- Mechanisms of intron gain and loss in Drosophila.BMC evolutionary biology · 2011Article
- Intron creation and DNA repair.Cellular and molecular life sciences : CMLS · 2011Review
- Article
- Phylogenetic distribution of intron positions in alpha-amylase genes of bilateria suggests numerous gains and losses.PloS one · 2011Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The genomes of the nematodes Caenorhabditis elegans and Caenorhabditis briggsae both contain approximately 100,000 introns, of which >6,000 are unique to one or the other species. To study the origins of new introns, we used a conservative method involving phylogenetic comparisons to animal orthologs and nematode paralogs to identify cases where an intron content difference between C. elegans and C. briggsae was caused by intron insertion rather than deletion. We identified 81 recently gained introns in C. elegans and 41 in C. briggsae. Novel introns have a stronger exon splice site consensus sequence than the general population of introns and show the same preference for phase 0 sites in codons over phases 1 and 2. More of the novel introns are inserted in genes that are expressed in the C. elegans germ line than expected by chance. Thirteen of the 122 gained introns are in genes whose protein products function in premRNA processing, including three gains in the gene for spliceosomal protein SF3B1 and two in the nonsense-mediated decay gene smg-2. Twenty-eight novel introns have significant DNA sequence identity to other introns, including three that are similar to other introns in the same gene. All of these similarities involve minisatellites or palindromes in the intron sequences. Our results suggest that at least some of the intron gains were caused by reverse splicing of a preexisting intron.
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