ArticleThe Journal of physiology2004
Action potential duration determines sarcoplasmic reticulum Ca2+ reloading in mammalian ventricular myocytes.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 55 citations in OpenAlex.
- Functionally Isolated Sarcoplasmic Reticulum in Cardiomyocytes: Experimental and Mathematical Models.Bioengineering (Basel, Switzerland) · 2025Article
- Heterogeneity of ventricular action potentials in neonatal rat cardiomyocytes and methodological aspects of patch clamp measurements.Frontiers in physiology · 2025Article
- Indoxyl sulfate reduces Ito,f by activating ROS/MAPK and NF-κB signaling pathways.JCI insight · 2022Article
- The transient outward potassium current plays a key role in spiral wave breakup in ventricular tissue.American journal of physiology. Heart and circulatory physiology · 2021Article
- Polycystin-1 Assembles With Kv Channels to Govern Cardiomyocyte Repolarization and Contractility.Circulation · 2019Article
- Altered Repolarization Reserve in Failing Rabbit Ventricular Myocytes: Calcium and β-Adrenergic Effects on Delayed- and Inward-Rectifier Potassium Currents.Circulation. Arrhythmia and electrophysiology · 2018Article
- Membrane potential determines calcium alternans through modulation of SR CaJournal of molecular and cellular cardiology · 2017Article
- Alternans in atria: Mechanisms and clinical relevance.Medicina (Kaunas, Lithuania) · 2017Review
- Species-Dependent Mechanisms of Cardiac Arrhythmia: A Cellular Focus.Clinical Medicine Insights. Cardiology · 2017Review
- Ca(2+)-activated chloride channel activity during Ca(2+) alternans in ventricular myocytes.Channels (Austin, Tex.) · 2016Article
- Calcium-activated chloride current determines action potential morphology during calcium alternans in atrial myocytes.The Journal of physiology · 2016Article
- Persistent increases in Ca(2+) influx through Cav1.2 shortens action potential and causes Ca(2+) overload-induced afterdepolarizations and arrhythmias.Basic research in cardiology · 2016Article
- The mechanisms of calcium cycling and action potential dynamics in cardiac alternans.Circulation research · 2015Article
- Complex excitation dynamics underlie polymorphic ventricular tachycardia in a transgenic rabbit model of long QT syndrome type 1.Heart rhythm · 2015Article
- Modulation of ventricular transient outward K⁺ current by acidosis and its effects on excitation-contraction coupling.American journal of physiology. Heart and circulatory physiology · 2013Article
- Role of the transient outward potassium current in the genesis of early afterdepolarizations in cardiac cells.Cardiovascular research · 2012Article
- Models of HERG gating.Biophysical journal · 2011Article
- Ionic mechanisms of cellular electrical and mechanical abnormalities in Brugada syndrome.American journal of physiology. Heart and circulatory physiology · 2011Article
- Control of Ca2+ release by action potential configuration in normal and failing murine cardiomyocytes.Biophysical journal · 2010Article
- Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers.The Journal of clinical investigation · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
After sarcoplasmic reticulum (SR) Ca2+ depletion in intact ventricular myocytes, electrical activity promotes SR Ca2+ reloading and recovery of twitch amplitude. In ferret, recovery of twitch and caffeine-induced contracture required fewer twitches than in rabbit or rat. In rat, there was no difference in action potential duration at 90% repolarization (APD90) at steady state (SS) versus at the first post-depletion (PD) twitch. The SS APD90 was similar in ferret and rabbit (but longer than in rat). However, compared to SS, the PD APD90 was lengthened in ferret, but shortened in rabbit. When rabbit myocytes were subjected to AP-clamp patterns during SR Ca2+ reloading (ferret- or rabbit-type APs), reloading was much faster using the ferret AP templates. We conclude that the faster SR Ca2+ refilling in ferret is due to the increased Ca2+ influx during the longer PD AP. The PD versus SS APD90 difference was suppressed by thapsigargin in ferret (indicating Ca2+ dependence). In rabbit, the PD AP shortening depended on the preceding diastolic interval (rather than Ca2+), because rest produced the same AP shortening, and SS APD90 increased as a function of frequency (in contrast to ferret). Transient outward current (Ito) was larger and recovered from inactivation much faster in ferret than in rabbit. Moreover, slow Ito recovery (tau approximately 3 s) in rabbit was a much larger fraction of Ito. Our data and a computational model (including two Ito components) suggest that in rabbit the slowly recovering Ito is responsible for short post-rest and PD APs, for the unusual frequency dependence of APD90, and ultimately for the slower post-depletion SR Ca2+ reloading.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.