ArticleThe Journal of physiology2004
Postural and locomotor control in normal and vestibularly deficient mice.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 70 citations in OpenAlex.
- Posture and support geometry, rather than body size, dictate lateral dynamic stability in walking mammalian quadrupeds.bioRxiv : the preprint server for biology · 2026Article
- Eye-head coordination during goal-directed orienting in mice.Communications biology · 2026Article
- Eye-head coordination during goal-directed orienting in mice.bioRxiv : the preprint server for biology · 2026Article
- Foot placement control underlies stable locomotion across species.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Low level of expression of known deafness genes Kcne1, Kcnj10 or Col4a3 is sufficient to maintain hearing in mice.Hearing research · 2025Article
- Instrumented swim test for quantifying motor impairment in rodents.Scientific reports · 2024Article
- An open-source tool for automated human-level circling behavior detection.Scientific reports · 2024Article
- Sensory feedback and central neuronal interactions in mouse locomotion.Royal Society open science · 2024Article
- Sensory Feedback and Central Neuronal Interactions in Mouse Locomotion.bioRxiv : the preprint server for biology · 2023Article
- An Open-Source Tool for Automated Human-Level Circling Behavior Detection.bioRxiv : the preprint server for biology · 2023Article
- Investigation of the Relationship between Vestibular Disorders and Sleep Disturbance.International archives of otorhinolaryngology · 2022Article
- Hypothalamic Control of Forelimb Motor Adaptation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Article
- Mouse Extraocular Muscles and the Musculotopic Organization of Their Innervation.Anatomical record (Hoboken, N.J. : 2007) · 2019Article
- Spontaneous mutations of the Zpld1 gene in mice cause semicircular canal dysfunction but do not impair gravity receptor or hearing functions.Scientific reports · 2019Article
- Developmental Vitamin D Deficiency Produces Behavioral Phenotypes of Relevance to Autism in an Animal Model.Nutrients · 2019Article
- Fitting unanchored puzzle pieces in the skeleton: appropriate 3D scapular positions for the quadrupedal support in tetrapods.Journal of anatomy · 2018Article
- A Circuit for Integration of Head- and Visual-Motion Signals in Layer 6 of Mouse Primary Visual Cortex.Neuron · 2018Article
- An intronic mutation in Chd7 creates a cryptic splice site, causing aberrant splicing in a mouse model of CHARGE syndrome.Scientific reports · 2018Article
- The statistics of the vestibular input experienced during natural self-motion differ between rodents and primates.The Journal of physiology · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated how vestibular information is used to maintain posture and control movement by studying vestibularly deficient mice (IsK-/- mutant). In these mutants, microscopy showed degeneration of the cristae of the semicircular canals and of the maculae of the utriculi and sacculi, while behavioural and vestibulo-ocular reflex testing showed that vestibular function was completely absent. However, the histology of Scarpa's ganglia and the vestibular nerves was normal in mutant mice, indicating the presence of intact central pathways. Using X-ray and high-speed cineradiography, we compared resting postures and locomotion patterns between these vestibularly deficient mice and vestibularly normal mice (wild-type and IsK+/-). The absence of vestibular function did not affect resting posture but had profound effects on locomotion. At rest, the S-shaped, sagittal posture of the vertebral column was the same for wild-type and mutant mice. Both held the head with the atlanto-occipital joint fully flexed, the cervico-thoracic junction fully flexed, and the cervical column upright. Wild-type mice extended the head and vertebral column and could walk in a straight line. In marked contrast, locomotion in vestibularly deficient mice was characterized by circling episodes, during which the vertebral column maintained an S-shaped posture. Thus, vestibular information is not required to control resting posture but is mandatory for normal locomotion. We propose that vestibular inputs are required to signal the completion of a planned trajectory because mutant mice continued rotating after changing heading direction. Our findings support the hypothesis that vertebrates limit the number of degrees of freedom to be controlled by adopting just a few of the possible skeletal configurations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.