ArticleJournal of clinical microbiology2004
Use of in vivo-generated biofilms from hemodialysis catheters to test the efficacy of a novel antimicrobial catheter lock for biofilm eradication in vitro.
Article in Journal of clinical microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 102 citations in OpenAlex.
- Minocycline-EDTA lock solution prevents catheter-related bacteremia in hemodialysis.Journal of the American Society of Nephrology : JASN · 2011Trial
- Use of 4% tetrasodium EDTA (KiteLock™) to prevent central venous catheter-related bloodstream infections in pediatric hemodialysis patients.Pediatric nephrology (Berlin, Germany) · 2025Article
- Extraction efficiency and bioactive evaluation of Tamarix nilotica and Arthrocnemum macrostachyum extracts for anti-cancer potential.PloS one · 2025Article
- Microbial contamination levels in water derived from dental units used in small animal dentistry.Frontiers in veterinary science · 2025Article
- Article
- Assessment of the ability of Pseudomonas aeruginosa and Staphylococcus aureus to create biofilms during wound healing in a rat model treated with carboxymethyl cellulose/carboxymethyl chitosan hydrogel containing EDTA.International wound journal · 2024Article
- Reevaluation of lock solutions for Central venous catheters in hemodialysis: a narrative review.Renal failure · 2022Review
- Antibacterial Activity of Some Molecules Added to Rabbit Semen Extender as Alternative to Antibiotics.Animals : an open access journal from MDPI · 2021Article
- Scanning electrochemical microscopy and its potential for studying biofilms and antimicrobial coatings.Analytical and bioanalytical chemistry · 2020Review
- Article
- Staphylococcus aureus extracellular vesicles (EVs): surface-binding antagonists of biofilm formation.Molecular bioSystems · 2017Article
- Antibiofilm agents: A new perspective for antimicrobial strategy.Journal of microbiology (Seoul, Korea) · 2017Review
- A quantitative method to measure biofilm removal efficiency from complex biomaterial surfaces using SEM and image analysis.Scientific reports · 2016Article
- Efficacy of a Low Dose of Hydrogen Peroxide (Peroxy Ag⁺) for Continuous Treatment of Dental Unit Water Lines: Challenge Test with Legionella pneumophila Serogroup 1 in a Simulated Dental Unit Waterline.International journal of environmental research and public health · 2016Article
- In Vitro Efficacy of Nonantibiotic Treatments on Biofilm Disruption of Gram-Negative Pathogens and an In Vivo Model of Infectious Endometritis Utilizing Isolates from the Equine Uterus.Journal of clinical microbiology · 2016Article
- EDTA: An Antimicrobial and Antibiofilm Agent for Use in Wound Care.Advances in wound care · 2015Review
- Bacterial biofilms: development, dispersal, and therapeutic strategies in the dawn of the postantibiotic era.Cold Spring Harbor perspectives in medicine · 2013Review
- EDTA inhibits biofilm formation, extracellular vesicular secretion, and shedding of the capsular polysaccharide glucuronoxylomannan by Cryptococcus neoformans.Applied and environmental microbiology · 2012Article
- Chitosan-EDTA new combination is a promising candidate for treatment of bacterial and fungal infections.Current microbiology · 2011Article
- Pellicle formation in Shewanella oneidensis.BMC microbiology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This biofilm study was conducted to assess the in vitro activity of tetrasodium EDTA on catheters that had been routinely removed from hemodialysis patients at Leeds Teaching Hospitals Trust due to maturation of fistula. Catheters were screened by culture of through-catheter flush, and isolates were identified by standard methodologies; 20 isolates were found to be biofilm positive. Initial biofilm cell count levels averaged above 10(5) CFU/1-cm catheter section. Bacteria identified in the biofilms were gram-negative (1 isolate), gram-positive (11 isolates), or mixed species (8 isolates). After a 24-h lock, 40 mg of tetrasodium EDTA per ml was effective at eradicating the total biofilm viable count in almost all cases. The efficacy of tetrasodium EDTA as a catheter lock potentially shows that this agent could substantially reduce catheter-related infections and be used to treat patients with limited access.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.