Evidence map›Paper›PMID 15243047›Full record

ArticleJournal of clinical microbiology2004

Intra- and interlaboratory study of a method for testing the antifungal susceptibilities of dermatophytes.

M A Ghannoum, V Chaturvedi, A Espinel-Ingroff, M A Pfaller, M G Rinaldi, W Lee-Yang, D W Warnock

Abstract read
In one paragraph

Article in Journal of clinical microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Trial
  2. Article
  3. Emergence of resistant dermatophytosis caused byMedical mycology case reports · 2025
    Article
  4. Emergence of terbinafine-resistantJournal of clinical microbiology · 2025
    Article
  5. In vitro Antifungal Susceptibility Profile of ClinicalInfection and drug resistance · 2025
    Article
  6. Article
  7. Review
  8. Phylogeny, Antifungal Susceptibility, and Point Mutations ofFrontiers in cellular and infection microbiology · 2022
    Article
  9. Virulence and Antifungal Susceptibility ofAntibiotics (Basel, Switzerland) · 2021
    Article
  10. Article
  11. Article
  12. Comparison of Four Methods for theFrontiers in microbiology · 2020
    Article
  13. A 9-Year Experience ofInfection and drug resistance · 2020
    Article
  14. Article
  15. Article
  16. Article
  17. Antifungal drug susceptibility profile of clinically important dermatophytes and determination of point mutations in terbinafine-resistant isolates.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018
    Article
  18. Therapy and Antifungal Susceptibility Profile ofJournal of fungi (Basel, Switzerland) · 2018
    Review
  19. Silicon phthalocyanine 4 phototoxicity in Trichophyton rubrum.Antimicrobial agents and chemotherapy · 2014
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

M A GhannoumCenter for Medical Mycology, University Hospitals of Cleveland/Case Western Reserve University, 11100 Euclid Ave., Cleveland, OH 44106-5028, USA. mag3@cwru.edu
V Chaturvedi
A Espinel-Ingroff
M A Pfaller
M G Rinaldi
W Lee-Yang
D W Warnock

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The National Committee for Clinical Laboratory Standards (NCCLS) M38-A standard for the susceptibility testing of conidium-forming filamentous fungi does not explicitly address the testing of dermatophytes. This multicenter study, involving six laboratories, investigated the MIC reproducibility of seven antifungal agents tested against 25 dermatophyte isolates (5 blinded pairs of five dermatophyte species per site for a total of 300 tests), using the method of dermatophyte testing developed at the Center for Medical Mycology, Cleveland, Ohio. The dermatophytes tested included Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Epidermophyton floccosum, and Microsporum canis. Seven antifungals with activity against dermatophytes were tested, including ciclopirox, fluconazole, griseofulvin, itraconazole, posaconazole, terbinafine, and voriconazole. Interlaboratory MICs for all isolates were in 92 to 100% agreement at a visual endpoint reading of 50% inhibition as compared to the growth control and 88 to 99% agreement at a visual endpoint reading of 80% inhibition as compared to the growth control. Intralaboratory MICs between blinded pairs were in 97% agreement at a visual endpoint reading of 50% inhibition as compared to the growth control and 96% agreement at a visual endpoint reading of 80% inhibition as compared to the growth control. Data from this study support consideration of this method as an amendment to the NCCLS M38-A standard for the testing of dermatophytes.

Indexed as

Antifungal AgentsArthrodermataceaeHumansLaboratoriesMicrobial Sensitivity TestsAntifungal Agents

Identifiers

PMID15243047
PMCPMC446243

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.