ArticleMolecular cancer2004
PTTG/securin activates expression of p53 and modulates its function.
Article in Molecular cancer, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 87 citations in OpenAlex.
- PTTG1-mediated the transcription of c-myc promotes retinoblastoma progression.Cell division · 2026Article
- Emerging Roles of PTTG1/Securin in Breast Cancer.Journal of Cancer · 2025Review
- IFIH1-mediated post-transcriptional regulation of PTTG1 promotes proliferation and affects PHA-848125 sensitivity and prognosis in oropharyngeal carcinoma.American journal of cancer research · 2024Article
- Key genes of renal tubular necrosis: a bioinformatics analysis.Translational andrology and urology · 2020Article
- Network analysis of DEGs and verification experiments reveal the notable roles of PTTG1 and MMP9 in lung cancer.Oncology letters · 2018Article
- Elevated PTTG and PBF predicts poor patient outcome and modulates DNA damage response genes in thyroid cancer.Oncogene · 2017Article
- Targeting polo-like kinase 1, a regulator of p53, in the treatment of adrenocortical carcinoma.Clinical and translational medicine · 2016Article
- Gene expression profiling analysis of MENX-associated rat pituitary adenomas contributes to understand molecular mechanisms of human pituitary adenomas.Oncology letters · 2016Article
- PTTG1 expression is associated with hyperproliferative disease and poor prognosis in multiple myeloma.Journal of hematology & oncology · 2015Article
- FoxM1 transactivates PTTG1 and promotes colorectal cancer cell migration and invasion.BMC medical genomics · 2015Article
- Positive and negative regulation of vertebrate separase by Cdk1-cyclin B1 may explain why securin is dispensable.The Journal of biological chemistry · 2015Article
- TFE2 and GATA3 enhance induction of POU4F3 and myosin VIIa positive cells in nonsensory cochlear epithelium by ATOH1.Developmental biology · 2012Article
- The pituitary tumor transforming gene in thyroid cancer.Journal of endocrinological investigation · 2012Review
- Regulation of POU4F3 gene expression in hair cells by 5' DNA in mice.Neuroscience · 2011Article
- Pituitary tumor transforming gene-1 haplotypes and risk of pituitary adenoma: a case-control study.BMC medical genetics · 2011Article
- Effect of PTTG on endogenous gene expression in HEK 293 cells.BMC genomics · 2009Article
- Road to the crossroads of life and death: linking sister chromatid cohesion and separation to aneuploidy, apoptosis and cancer.Critical reviews in oncology/hematology · 2009Review
- PTTG: an important target gene for ovarian cancer therapy.Journal of ovarian research · 2008Article
- Effect of separase depletion on ionizing radiation-induced cell cycle checkpoints and survival in human lung cancer cell lines.Cell proliferation · 2008Article
- Genomic view of IFN-alpha response in pre-autoimmune NZB/W and MRL/lpr mice.Genes and immunity · 2007Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPituitary tumor transforming gene (PTTG) is a novel oncogene that is expressed abundantly in most tumors. Overexpression of PTTG induces cellular transformation and promotes tumor formation in nude mice. PTTG has been implicated in various cellular processes including sister chromatid separation during cell division as well as induction of apoptosis through p53-dependent and p53-independent mechanisms. The relationship between PTTG and p53 remains unclear, however.
resultsHere we report the effects of overexpression of PTTG on the expression and function of p53. Our results indicate that overexpression of PTTG regulates the expression of the p53 gene at both the transcriptional and translational levels and that this ability of PTTG to activate the expression of p53 gene is dependent upon the p53 status of the cell. Deletion analysis of the p53 gene promoter revealed that only a small region of the p53 gene promoter is required for its activation by PTTG and further indicated that the activation of p53 gene by PTTG is an indirect effect that is mediated through the regulation of the expression of c-myc, which then interacts with the p53 gene promoter. Our results also indicate that overexpression of PTTG stimulates expression of the Bax gene, one of the known downstream targets of p53, and induces apoptosis in a human embryonic kidney cell line (HEK293). This stimulation of bax expression by PTTG is indirect and is mediated through modulation of p53 gene expression.
conclusionsOverexpression of PTTG activates the expression of p53 and modulates its function, with this action of PTTG being mediated through the regulation of c-myc expression. PTTG also up-regulates the activity of the bax promoter and increases the expression of bax through modulation of p53 expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.