ArticleBMC neuroscience2004
Growth cone pathfinding: a competition between deterministic and stochastic events.
Article in BMC neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The geometry of photopolymerized topography influences neurite pathfinding by directing growth cone morphology and migration.Journal of neural engineering · 2024Article
- Mathematical models of neuronal growth.Biomechanics and modeling in mechanobiology · 2022Review
- Anisometric Microstructures to Determine Minimal Critical Physical Cues Required for Neurite Alignment.Advanced healthcare materials · 2021Article
- A Statistically-Oriented Asymmetric Localization (SOAL) Model for Neuronal Outgrowth Patterning byGenetics · 2018Article
- A mathematical model explains saturating axon guidance responses to molecular gradients.eLife · 2016Article
- Synergistic effects of 3D ECM and chemogradients on neurite outgrowth and guidance: a simple modeling and microfluidic framework.PloS one · 2014Article
- Controlling neurite outgrowth with patterned substrates.Journal of biomedical materials research. Part A · 2011Article
- The interplay between branching and pruning on neuronal target search during developmental growth: functional role and implications.PloS one · 2011Article
- NETMORPH: a framework for the stochastic generation of large scale neuronal networks with realistic neuron morphologies.Neuroinformatics · 2009Article
- Cellular morphogenesis in silico.Biophysical journal · 2009Article
- The stochastic search dynamics of interneuron migration.Biophysical journal · 2009Article
- Mathematical modelling and numerical simulation of the morphological development of neurons.BMC neuroscience · 2006Article
- Cell orientation by a microgrooved substrate can be predicted by automatic control theory.Biophysical journal · 2006Article
- Computational approaches for modeling regulatory cellular networks.Trends in cell biology · 2004Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGrowth cone migratory patterns show evidence of both deterministic and stochastic search modes.
resultsWe quantitatively examine how these two different migration modes affect the growth cone's pathfinding response, by simulating growth cone contact with a repulsive cue and measuring the resultant turn angle. We develop a dimensionless number, we call the determinism ratio Psi, to define the ratio of deterministic to stochastic influences driving the growth cone's migration in response to an external guidance cue. We find that the growth cone can exhibit three distinct types of turning behaviors depending on the magnitude of Psi.
conclusionsWe conclude, within the context of these in silico studies, that only when deterministic and stochastic migration factors are in balance (i.e. Psi ~ 1) can the growth cone respond constructively to guidance cues.
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