Interleukin-6 and insulin sensitivity: friend or foe?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

47 citing papers in PubMed, 3 syntheses or guidelines pooled it.

1. The effect of low-carbohydrate diets, based on changes in intake of dietary saturated fats on circulating TNF-α and interleukin- 6 levels in adults: a systematic review and meta-analysis of randomized controlled trials.BMC nutrition · 2025
   Pooled it
2. The effect of sodium-glucose co-transporter-2 (SGLT2) inhibitors on blood interleukin-6 concentration: a systematic review and meta-analysis of randomized controlled trials.BMC endocrine disorders · 2023
   Pooled it
3. Inflammatory markers and bariatric surgery: a meta-analysis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012
   Pooled it
4. The Effects of Aerobic-Resistance Training and Broccoli Supplementation on Plasma Dectin-1 and Insulin Resistance in Males with Type 2 Diabetes.Nutrients · 2021
   Trial
5. Effects of chronic exercise training on inflammatory markers in Australian overweight and obese individuals in a randomized controlled trial.Inflammation · 2013
   Trial
6. Acute effects of dietary fat on inflammatory markers and gene expression in first-degree relatives of type 2 diabetes patients.The review of diabetic studies : RDS · 2011
   Trial
7. Immunology of Physical Exercise: IsInternational journal of molecular sciences · 2024
   Review
8. Association of pro-inflammatory cytokines, adipokines and hepatokine with incident diabetes in India: a nested case-control study within CARRS cohort.Acta diabetologica · 2024
   Article
9. Targeting inerleukin-6 for renoprotection.Frontiers in immunology · 2024
   Review
10. Regulation of systemic metabolism by tissue-resident immune cell circuits.Immunity · 2023
    Review
11. Impact of Moderate Physical Activity on Inflammatory Markers and Telomere Length in Sedentary and Moderately Active Individuals with Varied Insulin Sensitivity.Journal of inflammation research · 2023
    Article
12. Antioxidant and Anti-Inflammatory Effect of the Consumption of Powdered Concentrate ofAntioxidants (Basel, Switzerland) · 2022
    Article
13. β-Klotho promotes glycolysis and glucose-stimulated insulin secretion via GP130.Nature metabolism · 2022
    Article
14. Modulatory effect of resveratrol and melatonin on natural killer cell activity and adrenomedullin in diabetic rats.Turkish journal of medical sciences · 2022
    Article
15. Physical activity and adipokine levels in individuals with type 2 diabetes: A literature review and practical applications.Reviews in endocrine & metabolic disorders · 2021
    Review
16. Physical activity and exercise as an essential medical strategy for the COVID-19 pandemic and beyond.Experimental biology and medicine (Maywood, N.J.) · 2021
    Article
17. Immunoendocrine Dysregulation during Gestational Diabetes Mellitus: The Central Role of the Placenta.International journal of molecular sciences · 2021
    Review
18. Inhibition of Aurora-A improves insulin resistance by ameliorating islet inflammation and controlling interleukin-6 in a diabetic mouse model.Adipocyte · 2020
    Article
19. Intraperitoneal, but not retroperitoneal, visceral adipose tissue is associated with diabetes mellitus: a cross-sectional, retrospective pilot analysis.Diabetology & metabolic syndrome · 2020
    Article
20. Bioinformatic Reconstruction and Analysis of Gene Networks Related to Glucose Variability in Diabetes and Its Complications.International journal of molecular sciences · 2020
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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