SynthesisDiabetologia2004
Plasma insulin and cardiovascular mortality in non-diabetic European men and women: a meta-analysis of data from eleven prospective studies.
Synthesis in Diabetologia, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Fasting insulin, insulin resistance, and risk of cardiovascular or all-cause mortality in non-diabetic adults: a meta-analysis.Bioscience reports · 2017Pooled it
- Fasting insulin concentrations and incidence of hypertension, stroke, and coronary heart disease: a meta-analysis of prospective cohort studies.The American journal of clinical nutrition · 2013Pooled it
- Insulin resistance and risk of incident cardiovascular events in adults without diabetes: meta-analysis.PloS one · 2012Pooled it
- Insulin degludec requires lower bolus insulin doses than does insulin glargine in Japanese diabetic patients with insulin-dependent state.Journal of diabetes science and technology · 2015Trial
- Quantifying cardiometabolic risk using modifiable non-self-reported risk factors.American journal of preventive medicine · 2014Trial
- Association of long-term insulin variability before the onset of diabetes with cardiovascular outcomes in later life: Findings from the coronary artery risk development in young adults (CARDIA) study.American journal of preventive cardiology · 2025Article
- Deep learning of movement behavior profiles and their association with markers of cardiometabolic health.BMC medical informatics and decision making · 2024Article
- Anthropometric and Biochemical Correlations of Insulin Resistance in a Middle-Aged Maltese Caucasian Population.Journal of nutrition and metabolism · 2024Article
- Association of time-varying sleep duration and cognitive function with mortality in the elderly: a 12-year community-based cohort study.BMC psychiatry · 2023Article
- Evaluating Triglyceride and Glucose Index as a Simple and Easy-to-Calculate Marker for All-Cause and Cardiovascular Mortality.Journal of general internal medicine · 2022Article
- Prevalence rates of metabolic health and body size phenotypes by different criteria and association with insulin resistance in a Maltese Caucasian population.BMC endocrine disorders · 2022Article
- The Association BetweenDiabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Relationship among Insulin Therapy, Insulin Resistance, and Severe Coronary Artery Disease in Type 2 Diabetes Mellitus.Journal of interventional cardiology · 2022Observational
- A Clinical Study to Evaluate the Association Between Metabolic Syndrome and Sensorineural Hearing Loss.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2021Article
- The effects of insulin therapy on mortality in diabetic patients undergoing percutaneous coronary intervention.Annals of translational medicine · 2021Article
- The Epidemiological Boehringer Ingelheim Employee Study (Part 3): Association of Elevated Fasting Insulin Levels but Not HOMA-IR With Increased Intima Media Thickness and Arteriosclerosis in Middle-Aged Persons.Frontiers in cardiovascular medicine · 2021Article
- Article
- Non-Alcoholic Fatty Liver Disease Markers Associated with Fasting Serum Insulin and Urinary Albumin Excretion Independent of Fasting Plasma Glucose.Journal of clinical medicine · 2020Article
- Impact of weight variability on mortality among Korean men and women: a population based study.Scientific reports · 2019Article
- TG : HDL-C Ratio Is a Good Marker to Identify Children Affected by Obesity with Increased Cardiometabolic Risk and Insulin Resistance.International journal of endocrinology · 2019Article
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
aims/hypothesisWe examined the association between plasma insulin and cardiovascular mortality in non-diabetic European men and women based on data from eleven prospective studies.
methodsThe study population comprised 6156 men and 5351 women aged 30-89 years. Baseline measurements included oral glucose tolerance test, fasting and 2-h plasma insulin, and conventional risk factors. Cox models were used to calculate hazard ratios (HRs) and their 95% confidence intervals, and overall HRs were assessed by meta-analyses.
resultsDuring the 8.8-year follow-up, 362 men and 70 women died from cardiovascular disease. The age- and smoking-adjusted overall HR of cardiovascular mortality for the highest vs the lower quartiles of fasting insulin was 1.58 (95% CI: 1.26-1.97) in men and 2.64 (1.54-4.51) in women. Adjusting for other risk factors in addition, the HR was 1.54 (1.16-2.03) in men and 2.66 (1.45-4.90) in women. For 2-h insulin these HRs were 1.28 (0.99-1.66), 1.87 (0.87-4.02), and 0.85 (0.60-1.21), 1.36 (0.53-3.45). The overall HRs for interquartile ranges for fasting and 2-h insulin, with full adjustment, were 1.13 (1.05-1.22) and 1.11 (1.01-1.23) in men, and 1.25 (1.08-1.45) and 1.11 (0.91-1.36) in women. CONCLUSIONS/
interpretationHyperinsulinaemia, defined by the highest quartile cut-off for fasting insulin, was significantly associated with cardiovascular mortality in both men and women independently of other risk factors. Associations between high 2-h insulin and cardiovascular mortality were weaker and non-significant. Weak positive associations of fasting and 2-h insulin with cardiovascular mortality over interquartile ranges were, however, more similar.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.