ArticleMolecular psychiatry2004
Fine mapping of 10q and 18q for familial Alzheimer's disease in Caribbean Hispanics.
Article in Molecular psychiatry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications.Molecular neurodegeneration · 2012Pooled it
- Article
- Article
- Identification of putative causal loci in whole-genome sequencing data via knockoff statistics.Nature communications · 2021Article
- Genetic of Alzheimer's Disease: A Narrative Review Article.Iranian journal of public health · 2015Review
- Genetics of Alzheimer's disease in Caribbean Hispanic and African American populations.Biological psychiatry · 2014Review
- Carnosinases, their substrates and diseases.Molecules (Basel, Switzerland) · 2014Review
- Association studies of several cholesterol-related genes (ABCA1, CETP and LIPC) with serum lipids and risk of Alzheimer's disease.Lipids in health and disease · 2012Article
- The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE.Neurobiology of aging · 2012Review
- Panel of Genetic Variations as a Potential Non-invasive Biomarker for Early Diagnosis of Alzheimer's Disease.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2011Article
- Genetic loci modulating amyloid-beta levels in a mouse model of Alzheimer's disease.Neurobiology of aging · 2008Article
- Further examination of the candidate genes in chromosome 12p13 locus for late-onset Alzheimer disease.Neurogenetics · 2008Article
- Age-at-onset linkage analysis in Caribbean Hispanics with familial late-onset Alzheimer's disease.Neurogenetics · 2008Article
- Brain type carnosinase in dementia: a pilot study.BMC neurology · 2007Article
- Genetics of Alzheimer's disease: a centennial review.Neurologic clinics · 2007Review
- The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.Nature genetics · 2007Article
- Single-nucleotide polymorphism rs498055 on chromosome 10q24 is not associated with Alzheimer disease in two independent family samples.American journal of human genetics · 2006Article
- Clinical applications of Genome Polymorphism Scans.Biology direct · 2006Article
- Genetic association of ubiquilin with Alzheimer's disease and related quantitative measures.Molecular psychiatry · 2006Article
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Authors and funding
20 authors.
Funding
Abstract
Familial Alzheimer's disease (AD [MIM 104300]) has been a focus of intense investigation, primarily in Caucasian families from Europe and North America families. Although the late-onset form of familial AD, beginning after age 65 years, has been linked to regions on chromosomes 10q and 12p, the specific genetic variants have not yet been consistently identified. Using a unique cohort of families of Caribbean Hispanics ancestry, we screened the genome using 340 markers on 490 family members from 96 families with predominantly late-onset AD. We observed the strongest support for linkage on 18q (LOD=3.14). However, 17 additional markers (chromosomes 1-6, 8, 10, 12, and 14) exceeded a two-point LOD score of 1.0 under the affecteds-only autosomal dominant model or affected sibpair model. As we previously reported the fine-mapping effort on 12p showing modest evidence of linkage, we focused our fine-mapping efforts on two other candidate regions in the current report, namely 10q and 18q. We added 31 family members and eight additional Caribbean Hispanic families to fine map 10q and 18q. With additional microsatellite markers, the evidence for linkage for 18q strengthened near 112 cM, where the two-point LOD score for D18S541 was 3.37 and the highest NPL score in that region was 3.65 (P=0.000177). This narrow region contains a small number of genes expressed in the brain. However, at 10q (134-138 cM), the NPL score decreased from 3.15 (P=0.000486) to 2.1 (P=0.0218), but two broad peaks remained overlapping with previously reported peaks. Our results provide modest support for linkage on 10q and 12p in this cohort of Caribbean Hispanic families with familial Alzheimer's disease, and strong evidence for a new locus on 18q.
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