ArticleJournal of biomedicine & biotechnology2004
Serial Analysis of Gene Expression: Applications in Malaria Parasite, Yeast, Plant, and Animal Studies.
Article in Journal of biomedicine & biotechnology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Methodology optimizing SAGE library tag-to-gene mapping: application to Leishmania.BMC research notes · 2012Article
- In-depth global analysis of transcript abundance levels in porcine alveolar macrophages following infection with porcine reproductive and respiratory syndrome virus.Advances in virology · 2010Article
- Simultaneous gene expression profiling in human macrophages infected with Leishmania major parasites using SAGE.BMC genomics · 2008Article
- The maize root transcriptome by serial analysis of gene expression.Plant physiology · 2005Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The serial analysis of gene expression (SAGE) method is based on the isolation of unique sequence tags from individual transcripts and concatenation of tags serially into long DNA molecules. SAGE is an innovative technique that offers the potential of cataloging both the identity and relative frequencies of mRNA transcripts in a given RNA preparation. It can quantify low-abundance transcripts and reliably detect relatively small differences in transcript abundance between cell populations. SAGE data can be used to complement studies in cases where other gene expression methods may be more convenient or efficient. SAGE can be used in a wide variety of applications to identify disease-related genes, to analyze the effect of drugs on tissues, and to provide insights into the disease pathways. The most important application of SAGE is the identification of differentially expressed genes. In this review, we describe various applications of this powerful technology in malarial parasite, yeast, plant, and animal systems.
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Registered trials
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