ArticleBiophysical journal2004
Analysis of functional coupling: mitochondrial creatine kinase and adenine nucleotide translocase.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 75 citations in OpenAlex.
- Linking Cell Architecture to Mitochondrial Signaling in Neurodegeneration: The Role of Intermediate Filaments.International journal of molecular sciences · 2025Review
- Rat and mouse cardiomyocytes show subtle differences in creatine kinase expression and compartmentalization.PloS one · 2023Article
- Kinetic Mathematical Modeling of Oxidative Phosphorylation in Cardiomyocyte Mitochondria.Cells · 2022Review
- Article
- Effect of crista morphology on mitochondrial ATP output: A computational study.Current research in physiology · 2021Article
- Review
- Metabolic compartmentation in rainbow trout cardiomyocytes: coupling of hexokinase but not creatine kinase to mitochondrial respiration.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Article
- Review
- Mitochondrial complex II is a source of the reserve respiratory capacity that is regulated by metabolic sensors and promotes cell survival.Cell death & disease · 2015Article
- The location of energetic compartments affects energetic communication in cardiomyocytes.Frontiers in physiology · 2014Article
- Molecular dynamics simulations of creatine kinase and adenine nucleotide translocase in mitochondrial membrane patch.The Journal of biological chemistry · 2012Article
- Obstructed metabolite diffusion within skeletal muscle cells in silico.Molecular and cellular biochemistry · 2011Article
- Analyzing the functional properties of the creatine kinase system with multiscale 'sloppy' modeling.PLoS computational biology · 2011Article
- Symbolic flux analysis for genome-scale metabolic networks.BMC systems biology · 2011Article
- The creatine kinase system and pleiotropic effects of creatine.Amino acids · 2011Review
- Comparative expression analysis of the phosphocreatine circuit in extant primates: Implications for human brain evolution.Journal of human evolution · 2011Article
- Modulation of energy transfer pathways between mitochondria and myofibrils by changes in performance of perfused heart.The Journal of biological chemistry · 2010Article
- ADP compartmentation analysis reveals coupling between pyruvate kinase and ATPases in heart muscle.Biophysical journal · 2010Article
- Application of the principles of systems biology and Wiener's cybernetics for analysis of regulation of energy fluxes in muscle cells in vivo.International journal of molecular sciences · 2010Review
- Intracellular diffusion restrictions in isolated cardiomyocytes from rainbow trout.BMC cell biology · 2009Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanism of functional coupling between mitochondrial creatine kinase (MiCK) and adenine nucleotide translocase (ANT) in isolated heart mitochondria is analyzed. Two alternative mechanisms are studied: 1), dynamic compartmentation of ATP and ADP, which assumes the differences in concentrations of the substrates between intermembrane space and surrounding solution due to some diffusion restriction and 2), direct transfer of the substrates between MiCK and ANT. The mathematical models based on these possible mechanisms were composed and simulation results were compared with the available experimental data. The first model, based on a dynamic compartmentation mechanism, was not sufficient to reproduce the measured values of apparent dissociation constants of MiCK reaction coupled to oxidative phosphorylation. The second model, which assumes the direct transfer of substrates between MiCK and ANT, is shown to be in good agreement with experiments--i.e., the second model reproduced the measured constants and the estimated ADP flux, entering mitochondria after the MiCK reaction. This model is thermodynamically consistent, utilizing the free energy profiles of reactions. The analysis revealed the minimal changes in the free energy profile of the MiCK-ANT interaction required to reproduce the experimental data. A possible free energy profile of the coupled MiCK-ANT system is presented.
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