ArticleBiophysical journal2004
New aspects of the alpha-helix to beta-sheet transition in stretched hard alpha-keratin fibers.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 245 citations in OpenAlex.
- Structure and Sulfur: Tuning the Viscoelastic and Surface Properties of Natural Keratin Fibers.ACS materials Au · 2026Article
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- Effect of Poly(l-serine) Additives with Different Primary Structures on the Mechanical Properties of Poly(vinyl alcohol) Films.Biomacromolecules · 2025Article
- Niacinamide and its impact on stratum corneum hydration and structure.Scientific reports · 2025Article
- Keratinous and corneous-based products towards circular bioeconomy: A research review.Environmental science and ecotechnology · 2024Review
- Quantifying the effects of repeated dyeing: Morphological, mechanical, and chemical changes in human hair fibers.Heliyon · 2024Article
- Electrospun Silk-ICG Composite Fibers and the Application toward Hemorrhage Control.Journal of functional biomaterials · 2024Article
- Ionic liquids inhibit the dynamic transition from αFundamental research · 2024Article
- Maturation and Conformational Switching of aJournal of the American Chemical Society · 2024Article
- Alterations promoted by acid straightening and/or bleaching in hair microstructures.Journal of applied crystallography · 2023Article
- Mechanical Behavior of Octopus Egg Tethers Composed of Topologically Constrained, Tandemly Repeated EGF Domains.Biomacromolecules · 2023Article
- Studies on Chemical Composition, Structure and Potential Applications ofInternational journal of molecular sciences · 2023Article
- Protein-Based Biological Materials: Molecular Design and Artificial Production.Chemical reviews · 2023Review
- Electrospun Silk Fibroin-CNT Composite Fibers: Characterization and Application in Mediating Fibroblast Stimulation.Polymers · 2022Article
- Sustainable Applications of Animal Waste Proteins.Polymers · 2022Review
- Analysis and comparison of protein secondary structures in the rachis of avian flight feathers.PeerJ · 2022Article
- Review
- Probing Skin Barrier Recovery on Molecular Level Following Acute Wounds: An In Vivo/Ex Vivo Study on Pigs.Biomedicines · 2021Article
- A bioinspired and hierarchically structured shape-memory material.Nature materials · 2021Article
- Structure of Keratin.Methods in molecular biology (Clifton, N.J.) · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The putative transformation of alpha-helices into beta-sheets has been studied for more than 50 years in the case of hard alpha-keratin. In a previous study of stretched keratin fibers, we specified the conditions for beta-sheet appearance within horsehair: the formation of beta-sheets requires at least 30% relative humidity. However, this phenomenon was observed in the whole tissue. Then there was no clear chemical identification of the beta-sheets (keratin or matrix proteins) and the exact location of the beta-sheets across the fiber could not be specified. In this study, using wide-angle x-ray scattering and high spatial resolution infrared microspectroscopy, we could determine and characterize the structural elements across hair sections stretched in water, which provides new information about the aforementioned transition. Our results show that the process can be split into three steps: 1), unraveling of the alpha-helical coiled-coil domains, which starts at roughly 5% macroscopic strain; 2), further transformation of the unraveled coiled-coils into beta-sheet structures, which occurs above roughly 20% macroscopic strain; and 3), spatial expanding of the beta-structured zones from the sample center to its periphery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.