ArticleBiophysical journal2004
Structural transients of contractile proteins upon sudden ATP liberation in skeletal muscle fibers.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Synchrotron radiation X-ray diffraction studies on muscle: past, present, and future.Biophysical reviews · 2019Review
- Synchrotron Radiation X-ray Diffraction Techniques Applied to Insect Flight Muscle.International journal of molecular sciences · 2018Review
- The earliest molecular response to stretch of insect flight muscle as revealed by fast X-ray diffraction recording.Scientific reports · 2017Article
- Disrupted myosin cross-bridge cycling kinetics triggers muscle weakness in nebulin-related myopathy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Article
- Fast x-ray recordings reveal dynamic action of contractile and regulatory proteins in stretch-activated insect flight muscle.Biophysical journal · 2010Article
- Dynamics of thin-filament activation in rabbit skeletal muscle fibers examined by time-resolved x-ray diffraction.Biophysical journal · 2009Article
- On the ability of 8-bromoadenosine triphosphate to support contractility of vertebrate skeletal muscle fibers.Journal of muscle research and cell motility · 2008Article
- Diversity of structural behavior in vertebrate conventional myosins complexed with actin.Journal of molecular biology · 2007Article
- A structural origin of latency relaxation in frog skeletal muscle.Biophysical journal · 2007Article
- Structural changes of cross-bridges on transition from isometric to shortening state in frog skeletal muscle.Biophysical journal · 2006Article
- Physiological consequences of thin filament cooperativity for vertebrate striated muscle contraction: a theoretical study.Journal of muscle research and cell motility · 2006Article
- Structural changes of actin-bound myosin heads after a quick length change in frog skeletal muscle.Biophysical journal · 2005Article
- Intensity of X-ray reflections from skeletal muscle thin filaments partially occupied with myosin heads: effect of cooperative binding.Journal of muscle research and cell motility · 2004Article
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Authors and funding
4 authors.
Funding
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Abstract
Structural changes of contractile proteins were examined by millisecond time-resolved two-dimensional x-ray diffraction recordings during relaxation of skinned skeletal muscle fibers from rigor after caged ATP photolysis. It is known that the initial dissociation of the rigor actomyosin complex is followed by a period of transient active contraction, which is markedly prolonged in the presence of ADP by a mechanism yet to be clarified. Both single-headed (overstretched muscle fibers with exogenous myosin subfragment-1) and two-headed (fibers with full filament overlap) preparations were used. Analyses of various actin-based layer line reflections from both specimens showed the following: 1), The dissociation of the rigor actomyosin complex was fast and only modestly decelerated by ADP and occurred in a single exponential manner without passing through any detectable transitory state. Its ADP sensitivity was greater in the two-headed preparation but fell short of explaining the large ADP effect on the transient active contraction. 2), The decay of the activated state of the thin filament followed the time course of tension more closely in an ADP-dependent manner. These results suggest that the interplay between the reattached active myosin heads and the thin filament is responsible for the prolonged active contraction in the presence of ADP.
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