ArticleBiophysical journal2004
Conformation of peptides in lipid membranes studied by x-ray grazing incidence scattering.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 94 citations in OpenAlex.
- Advancements of fish-derived peptides for mucormycosis: a novel strategy to treat diabetic compilation.Molecular biology reports · 2023Review
- Discovery of structural and functional transition sites for membrane-penetrating activity of sheep myeloid antimicrobial peptide-18.Scientific reports · 2023Article
- Grazing Incidence X-ray Diffraction Studies of Lipid-Peptide Mixed Monolayers during Shear Flow.ACS omega · 2020Article
- Switchable Membrane Remodeling and Antifungal Defense by Metamorphic Chemokine XCL1.ACS infectious diseases · 2020Article
- Short Cationic Peptidomimetic Antimicrobials.Antibiotics (Basel, Switzerland) · 2019Review
- What Can Pleiotropic Proteins in Innate Immunity Teach Us about Bioconjugation and Molecular Design?Bioconjugate chemistry · 2018Review
- The effect of gramicidin inclusions on the local order of membrane components.The European physical journal. E, Soft matter · 2018Article
- What can machine learning do for antimicrobial peptides, and what can antimicrobial peptides do for machine learning?Interface focus · 2017Review
- Lipid-packing perturbation of model membranes by pH-responsive antimicrobial peptides.Biophysical reviews · 2017Review
- Membrane-active peptides from marine organisms--antimicrobials, cell-penetrating peptides and peptide toxins: applications and prospects.Probiotics and antimicrobial proteins · 2015Review
- A thermodynamic approach to alamethicin pore formation.Biochimica et biophysica acta · 2014Article
- Antimicrobial peptides and induced membrane curvature: geometry, coordination chemistry, and molecular engineering.Current opinion in solid state & materials science · 2013Article
- Observing a model ion channel gating action in model cell membranes in real time in situ: membrane potential change induced alamethicin orientation change.Journal of the American Chemical Society · 2012Article
- Peptide model helices in lipid membranes: insertion, positioning, and lipid response on aggregation studied by X-ray scattering.European biophysics journal : EBJ · 2011Article
- In situ muGISAXS: II. Thaumatin crystal growth kinetic.Biophysical journal · 2010Article
- Interactions of alamethicin with model cell membranes investigated using sum frequency generation vibrational spectroscopy in real time in situ.The journal of physical chemistry. B · 2010Article
- In situ molecular level studies on membrane related peptides and proteins in real time using sum frequency generation vibrational spectroscopy.Journal of structural biology · 2009Review
- Alamethicin in lipid bilayers: combined use of X-ray scattering and MD simulations.Biochimica et biophysica acta · 2009Article
- Structure of self-aggregated alamethicin in ePC membranes detected by pulsed electron-electron double resonance and electron spin echo envelope modulation spectroscopies.Biophysical journal · 2009Article
- Structure and alignment of the membrane-associated peptaibols ampullosporin A and alamethicin by oriented 15N and 31P solid-state NMR spectroscopy.Biophysical journal · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the antimicrobial, fungal peptide alamethicin has been extensively studied, the conformation of the peptide and the interaction with lipid bilayers as well as the mechanism of channel gating are still not completely clear. As opposed to studies of the crystalline state, the polypeptide structures in the environment of fluid bilayers are difficult to probe. We have investigated the conformation of alamethicin in highly aligned stacks of model lipid membranes by synchrotron-based x-ray scattering. The (wide-angle) scattering distribution has been measured by reciprocal space mappings. A pronounced scattering signal is observed in samples of high molar peptide/lipid ratio which is distinctly different from the scattering distribution of an ideal helix in the transmembrane state. Beyond simple models of ideal helices, the data is analyzed in terms of models based on atomic coordinates from the Brookhaven Protein Data Bank, as well as from published molecular dynamics simulations. The results can be explained by assuming a wide distribution of helix tilt angles with respect to the membrane normal and a partial insertion of the N-terminus into the membrane.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.