ArticleBiophysical journal2004
Three roads to islet bursting: emergent oscillations in coupled phantom bursters.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- A primer on modelling pancreatic islets: from models of coupled β-cells to multicellular islet models.Islets · 2023Review
- Pancreatic α and β cells are globally phase-locked.Nature communications · 2022Article
- The physiological role of β-cell heterogeneity in pancreatic islet function.Nature reviews. Endocrinology · 2022Review
- Small subpopulations of β-cells do not drive islet oscillatory [Ca2+] dynamics via gap junction communication.PLoS computational biology · 2021Article
- How Heterogeneity in Glucokinase and Gap-Junction Coupling Determines the Islet [CaBiophysical journal · 2019Article
- Critical and Supercritical Spatiotemporal Calcium Dynamics in Beta Cells.Frontiers in physiology · 2017Article
- Intrinsic islet heterogeneity and gap junction coupling determine spatiotemporal Ca²⁺ wave dynamics.Biophysical journal · 2014Article
- Cellular communication and heterogeneity in pancreatic islet insulin secretion dynamics.Trends in endocrinology and metabolism: TEM · 2014Review
- Dimensionality and size scaling of coordinated Ca(2+) dynamics in MIN6 β-cell clusters.Biophysical journal · 2014Article
- Phase transitions in pancreatic islet cellular networks and implications for type-1 diabetes.Physical review. E, Statistical, nonlinear, and soft matter physics · 2014Article
- The effect of unhealthy β-cells on insulin secretion in pancreatic islets.BMC medical genomics · 2013Article
- Glucose metabolism, islet architecture, and genetic homogeneity in imprinting of [Ca2+](i) and insulin rhythms in mouse islets.PloS one · 2009Article
- Contributions of mathematical modeling of beta cells to the understanding of beta-cell oscillations and insulin secretion.Journal of diabetes science and technology · 2009Review
- Gap junction coupling and calcium waves in the pancreatic islet.Biophysical journal · 2008Article
- Investigating the role of islet cytoarchitecture in its oscillation using a new beta-cell cluster model.PloS one · 2007Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Glucose-induced membrane potential and Ca(2+) oscillations in isolated pancreatic beta-cells occur over a wide range of frequencies, from >6/min (fast) to <1/min (slow). However, cells within intact islets generally oscillate with periods of 10-60 s (medium). The phantom bursting concept addresses how beta-cells can generate such a wide range of frequencies. Here, we explore an updated phantom bursting model to determine how heterogeneity in a single parameter can explain both the broad frequency range observed in single cells and the rarity of medium oscillations. We then incorporate the single-cell model into an islet model with parameter heterogeneity. We show that strongly coupled islets must be composed of predominantly medium oscillating single cells or a mixture of fast and slow cells to robustly produce medium oscillations. Surprisingly, we find that this constraint does not hold for moderate coupling, and that robustly medium oscillating islets can arise from populations of single cells that are essentially all slow or all fast. Thus, with coupled phantom bursters, medium oscillating islets can be constructed out of cells that are either all fast, all slow, or a combination of the two.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.