ArticleApplied and environmental microbiology2004
Fur is involved in manganese-dependent regulation of mntA (sitA) expression in Sinorhizobium meliloti.
Article in Applied and environmental microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 60 citations in OpenAlex.
- The Mutation of the DNA-Binding Domain of Fur Protein Enhances the Pathogenicity ofMicroorganisms · 2023Article
- A Fur-regulated type VI secretion system contributes to oxidative stress resistance and virulence in Yersinia pseudotuberculosis.Stress biology · 2023Article
- Genetic Redundancy in Iron and Manganese Transport in the Metabolically Versatile Bacterium Rhodopseudomonas palustris TIE-1.Applied and environmental microbiology · 2020Article
- Multiple Sense and Antisense Promoters Contribute to the Regulated Expression of theMicroorganisms · 2019Article
- The Irr and RirA Proteins Participate in a Complex Regulatory Circuit and Act in Concert To Modulate Bacterioferritin Expression in Ensifer meliloti 1021.Applied and environmental microbiology · 2017Article
- Prokaryotic Heme Biosynthesis: Multiple Pathways to a Common Essential Product.Microbiology and molecular biology reviews : MMBR · 2017Review
- Metal-specific control of gene expression mediated by Bradyrhizobium japonicum Mur and Escherichia coli Fur is determined by the cellular context.Molecular microbiology · 2016Article
- Manganese uptake and streptococcal virulence.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2015Review
- Article
- Role of the Irr protein in the regulation of iron metabolism in Rhodobacter sphaeroides.PloS one · 2012Article
- The Fur regulon in anaerobically grown Salmonella enterica sv. Typhimurium: identification of new Fur targets.BMC microbiology · 2011Article
- Transcriptional control of the Bradyrhizobium japonicum irr gene requires repression by fur and Antirepression by Irr.The Journal of biological chemistry · 2010Article
- Deletion of a fur-like gene affects iron homeostasis and magnetosome formation in Magnetospirillum gryphiswaldense.Journal of bacteriology · 2010Article
- A new small regulatory protein, HmuP, modulates haemin acquisition in Sinorhizobium meliloti.Microbiology (Reading, England) · 2010Article
- Deletion of citrate synthase restores growth of Sinorhizobium meliloti 1021 aconitase mutants.Journal of bacteriology · 2009Article
- The manganese transporter MntH is a critical virulence determinant for Brucella abortus 2308 in experimentally infected mice.Infection and immunity · 2009Article
- The mntH gene encodes the major Mn(2+) transporter in Bradyrhizobium japonicum and is regulated by manganese via the Fur protein.Molecular microbiology · 2009Article
- Roles of Agrobacterium tumefaciens RirA in iron regulation, oxidative stress response, and virulence.Journal of bacteriology · 2009Article
- Heme-dependent metalloregulation by the iron response regulator (Irr) protein in Rhizobium and other Alpha-proteobacteria.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2009Article
- ShmR is essential for utilization of heme as a nutritional iron source in Sinorhizobium meliloti.Applied and environmental microbiology · 2008Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fur is a transcriptional regulator involved in iron-dependent control of gene expression in many bacteria. In this work we analyzed the phenotype of a fur mutant in Sinorhizobium meliloti, an alpha-proteobacterium that fixes N(2) in association with host plants. We demonstrated that some functions involved in high-affinity iron transport, siderophore production, and iron-regulated outer membrane protein expression respond to iron in a Fur-independent manner. However, manganese-dependent expression of the MntABCD manganese transport system was lost in a fur strain as discerned by constitutive expression of a mntA::gfp fusion reporter gene in the mutant. Thus, Fur directly or indirectly regulates a manganese-dependent function. The data indicate a novel function for a bacterial Fur protein in mediating manganese-dependent regulation of gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.