ArticleApplied and environmental microbiology2004
Relationship between gyrA mutations and quinolone resistance in Flavobacterium psychrophilum isolates.
Article in Applied and environmental microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 65 citations in OpenAlex.
- Identification and Characterization of Flavobacterium psychrophilum as a Causative Pathogen in Farmed Grass Carp Ctenopharyngodon idella in China.Journal of fish diseases · 2026Article
- Phenotypic and Genotypic Antimicrobial Resistance Profiles of Flavobacterium psychrophilum and Flavobacterium branchiophilum Isolated From Rainbow Trout (Oncorhynchus mykiss) in Slovenia.Journal of fish diseases · 2025Article
- Comparative genomic analysis of Flavobacterium species causing columnaris disease of freshwater fish in Thailand: insights into virulence and resistance mechanisms.BMC veterinary research · 2025Article
- Tenacibaculosis caused byFrontiers in cellular and infection microbiology · 2022Review
- Phage-Mediated Control ofFrontiers in microbiology · 2021Article
- Genome analysis provides insights into the epidemiology of infection with Flavobacterium psychrophilum among farmed salmonid fish in Sweden.Microbial genomics · 2018Article
- Antimicrobial Susceptibility ofFrontiers in microbiology · 2016Article
- Biocontrol and Plant Growth Promotion Characterization of Bacillus Species Isolated from Calendula officinalis Rhizosphere.Indian journal of microbiology · 2013Article
- Population structure of the fish pathogen Flavobacterium psychrophilum at whole-country and model river levels in Japan.Veterinary research · 2013Article
- Mechanisms of antimicrobial resistance in finfish aquaculture environments.Frontiers in microbiology · 2013Article
- Article
- Molecular analysis of the gyrA and gyrB quinolone resistance-determining regions of fluoroquinolone-resistant Clostridium difficile mutants selected in vitro.Antimicrobial agents and chemotherapy · 2009Article
- gyrA and parC Mutations and associated quinolone resistance in Vibrio anguillarum serotype O2b strains isolated from farmed Atlantic cod (Gadus morhua) in Norway.Antimicrobial agents and chemotherapy · 2007Article
- A protective immune response is generated in rainbow trout by an OmpH-like surface antigen (P18) of Flavobacterium psychrophilum.Applied and environmental microbiology · 2006Article
- Identification of a multidrug efflux pump in Flavobacterium johnsoniae.Veterinary researchArticle
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Authors and funding
2 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Flavobacterium psychrophilum is the causative agent of the fish diseases called bacterial cold-water disease and rainbow trout fry syndrome. It has been reported that some isolates of F. psychrophilum are resistant to quinolones; however, the mechanism of this quinolone resistance has been unexplained. In this study, we examined the quinolone susceptibility patterns of 27 F. psychrophilum strains isolated in Japan and the United States. Out of 27 isolates, 14 were resistant to both nalidixic acid (NA) and oxolinic acid (OXA), and the others were susceptible to NA and OXA. When amino acid sequences deduced from gyrA nucleotide sequences of all isolates tested were analyzed, two amino acid substitutions (a threonine residue replaced by an alanine or isoleucine residue in position 83 of GyrA [Escherichia coli numbering] and an aspartic acid residue replaced by a tyrosine residue in position 87) were observed in the 14 quinolone-resistant isolates. These results strongly suggest that, as in other gram-negative bacteria, DNA gyrase is an important target for quinolones in F. psychrophilum.
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