ArticleProtein science : a publication of the Protein Society2004
Modeling and simulation of the human delta opioid receptor.
Article in Protein science : a publication of the Protein Society, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Exploring the structure of opioid receptors with homology modeling based on single and multiple templates and subsequent docking: a comparative study.Journal of molecular modeling · 2011Article
- Insights into subtype selectivity of opioid agonists by ligand-based and structure-based methods.Journal of molecular modeling · 2011Article
- Probing a model of a GPCR/ligand complex in an explicit membrane environment: the human cholecystokinin-1 receptor.Biophysical journal · 2006Article
- Lipid bilayers on polyacrylamide brushes for inclusion of membrane proteins.Langmuir : the ACS journal of surfaces and colloids · 2005Article
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2 authors.
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Abstract
A model for the human delta opioid receptor has been generated via sequence alignment, structure building using the crystal structure of bovine rhodopsin as a template, and refinement by molecular dynamics simulation. The model building suggested that, in addition to the previously postulated interaction between D128 and Y308, an internal salt bridge also exists between residues D128 and R192, both of which are conserved in all the opioid receptors. The model and salt bridge were then shown to be stable during a 20-nsec simulation in a lipid bilayer. It is therefore proposed that both of these interactions play a role in stabilizing the inactive state of the receptor. The model is also used in an effort to rationalize many of the mutational studies performed on delta opioid receptors, and to suggest a plausible explanation for the differences between known delta opioid agonists and antagonists.
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Registered trials
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