ArticleGenetics2004
A potent modifier of liver cancer risk on distal mouse chromosome 1: linkage analysis and characterization of congenic lines.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Spontaneous Carcinoogenesis: Regulation of Adhesion Disorders and Cancer Prevention.Bulletin of experimental biology and medicine · 2025Article
- In Vivo and In Vitro Models of Hepatocellular Carcinoma: Current Strategies for Translational Modeling.Cancers · 2021Review
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- Sleeping Beauty Mouse Models of Cancer: Microenvironmental Influences on Cancer Genetics.Frontiers in oncology · 2019Review
- Fibrosis-associated hepatocarcinogenesis revisited: Establishing standard medium-term chemically-induced male and female models.PloS one · 2018Article
- DNA Alkylating Agent Protects Against Spontaneous Hepatocellular Carcinoma Regardless of O6-Methylguanine-DNA Methyltransferase Status.Cancer prevention research (Philadelphia, Pa.) · 2016Article
- Genetic background determines if Stat5b suppresses or enhances murine hepatocarcinogenesis.Molecular carcinogenesis · 2015Article
- TALEN-mediated somatic mutagenesis in murine models of cancer.Cancer research · 2014Article
- Liver tumor promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin is dependent on the aryl hydrocarbon receptor and TNF/IL-1 receptors.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Dose-dependent incidence of hepatic tumors in adult mice following perinatal exposure to bisphenol A.Environmental health perspectives · 2014Article
- Regulator of G-protein signaling-5 is a marker of hepatic stellate cells and expression mediates response to liver injury.PloS one · 2014Article
- Regulator of G-protein signaling - 5 (RGS5) is a novel repressor of hedgehog signaling.PloS one · 2013Article
- Tsc2, a positional candidate gene underlying a quantitative trait locus for hepatic steatosis.Journal of lipid research · 2012Article
- Gene deletions and amplifications in human hepatocellular carcinomas: correlation with hepatocyte growth regulation.The American journal of pathology · 2012Article
- Nuclear receptor CAR-regulated expression of the FAM84A gene during the development of mouse liver tumors.International journal of oncology · 2011Article
- Identification of susceptibility loci in a mouse model of KRASG12D-driven pancreatic cancer.Cancer research · 2010Article
- Predominant modifier of extreme liver cancer susceptibility in C57BR/cdJ female mice localized to 6 Mb on chromosome 17.Carcinogenesis · 2009Article
- Biological Basis of Differential Susceptibility to Hepatocarcinogenesis among Mouse Strains.Journal of toxicologic pathology · 2009Article
- Interaction of major genes predisposing to hepatocellular carcinoma with genes encoding signal transduction pathways influences tumor phenotype and prognosis.World journal of gastroenterology · 2008Article
- Ancestral bias in the Hras1 gene and distal Chromosome 7 among inbred mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The C3H/HeJ (C3H) and CBA/J (CBA) mouse strains are classical mouse models of cancer susceptibility, exhibiting high risks for both spontaneous and chemically induced liver cancer. By analysis of backcrosses and intercrosses between C3H or CBA and resistant B6 mice, we have mapped a potent modifier of hepatocellular carcinoma development to distal chromosome 1, linked to the marker D1Mit33 with combined LOD(W) scores of approximately 5.9 (C3H) and 6.5 (CBA). We previously identified this region as one of two that modify susceptibility in the more distantly related C57BR/cdJ (BR) strain. Congenic B6.C3H(D1Mit5-D1Mit17) and B6.BR(D1Mit5-D1Mit17) mice developed significantly more liver tumors than B6 mice did (6- to 13-fold, P < 10(-11), in males; 3- to 4-fold, P < 10(-3), in females). Thus, distal chromosome 1 carries one or more genes that are sufficient to confer susceptibility to liver cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.