ArticleGenetics2004
Estimates of the genomic mutation rate for detrimental alleles in Drosophila melanogaster.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Not just mutations: inbreeding depression persists without genetic variation.Evolution letters · 2026Article
- Influence of the mutation load on the genomic composition of hybrids between outcrossing and self-fertilizing species.Ecology and evolution · 2023Article
- Precise measurement of the fitness effects of spontaneous mutations by droplet digital PCR in Burkholderia cenocepacia.Genetics · 2021Article
- Review
- In defence of doing sums in genetics.Heredity · 2019Review
- Mitochondrial DNA Fitness Depends on Nuclear Genetic Background inG3 (Bethesda, Md.) · 2019Article
- Old Trade, New Tricks: Insights into the Spontaneous Mutation Process from the Partnering of Classical Mutation Accumulation Experiments with High-Throughput Genomic Approaches.Genome biology and evolution · 2019Review
- Fitness change in relation to mutation number in spontaneous mutation accumulation lines of Chlamydomonas reinhardtii.Evolution; international journal of organic evolution · 2017Article
- Article
- The Role of Deleterious Substitutions in Crop Genomes.Molecular biology and evolution · 2016Article
- Inbreeding depression under mixed outcrossing, self-fertilization and sib-mating.BMC evolutionary biology · 2016Article
- Causes of natural variation in fitness: evidence from studies of Drosophila populations.Proceedings of the National Academy of Sciences of the United States of America · 2015Review
- Spontaneous mutation accumulation in multiple strains of the green alga, Chlamydomonas reinhardtii.Evolution; international journal of organic evolution · 2014Article
- Effects of new mutations on fitness: insights from models and data.Annals of the New York Academy of Sciences · 2014Review
- The rate and effects of spontaneous mutation on fitness traits in the social amoeba, Dictyostelium discoideum.G3 (Bethesda, Md.) · 2013Article
- How important are transposons for plant evolution?Nature reviews. Genetics · 2013Review
- On measuring selection in experimental evolution.Biology letters · 2011Article
- Measurements of spontaneous rates of mutations in the recent past and the near future.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- The population genetics of mutations: good, bad and indifferent.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Article
- Molecular spectrum of spontaneous de novo mutations in male and female germline cells of Drosophila melanogaster.Genetics · 2009Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The net rate of mutation to deleterious but nonlethal alleles and the sizes of effects of these mutations are of great significance for many evolutionary questions. Here we describe three replicate experiments in which mutations have been accumulated on chromosome 3 of Drosophila melanogaster by means of single-male backcrosses of heterozygotes for a wild-type third chromosome. Egg-to-adult viability was assayed for nonlethal homozygous chromosomes. The rates of decline in mean and increase in variance (DM and DV, respectively) were estimated. Scaled up to the diploid whole genome, the mean DM for homozygous detrimental mutations over the three experiments was between 0.8 and 1.8%. The corresponding DV estimate was approximately 0.11%. Overall, the results suggest a lower bound estimate of at least 12% for the diploid per genome mutation rate for detrimentals. The upper bound estimates for the mean selection coefficient were between 2 and 10%, depending on the method used. Mutations with selection coefficients of at least a few percent must be the major contributors to the effects detected here and are likely to be caused mostly by transposable element insertions or indels.
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