ArticleGenetics2004
A genetic linkage map of Cryptococcus neoformans variety neoformans serotype D (Filobasidiella neoformans).
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 72 citations in OpenAlex.
- Discovery of CONature microbiology · 2024Article
- Mendelian segregation and high recombination rates facilitate genetic analyses in Cryptosporidium parvum.PLoS genetics · 2024Article
- Mendelian segregation and high recombination rates facilitate genetic analyses inbioRxiv : the preprint server for biology · 2024Article
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- Pleiotropy and epistasis within and between signaling pathways defines the genetic architecture of fungal virulence.PLoS genetics · 2021Article
- On the History and Applications of Congenic Strains inPathogens (Basel, Switzerland) · 2020Review
- A High-Resolution Map of Meiotic Recombination inGenetics · 2018Article
- From Two to One: Unipolar Sexual Reproduction.Fungal biology reviews · 2015Article
- Unisexual versus bisexual mating in Cryptococcus neoformans: Consequences and biological impacts.Fungal genetics and biology : FG & B · 2015Review
- Unisexual reproduction drives meiotic recombination and phenotypic and karyotypic plasticity in Cryptococcus neoformans.PLoS genetics · 2014Article
- Unisexual and heterosexual meiotic reproduction generate aneuploidy and phenotypic diversity de novo in the yeast Cryptococcus neoformans.PLoS biology · 2013Article
- Congenic strains of the filamentous form of Cryptococcus neoformans for studies of fungal morphogenesis and virulence.Infection and immunity · 2013Article
- Congenic strains for genetic analysis of virulence traits in Cryptococcus gattii.Infection and immunity · 2013Article
- Balancing stability and flexibility within the genome of the pathogen Cryptococcus neoformans.PLoS pathogens · 2013Article
- Cryptococcus gattii, no longer an accidental pathogen?Current fungal infection reports · 2012Article
- Gene conversion occurs within the mating-type locus of Cryptococcus neoformans during sexual reproduction.PLoS genetics · 2012Article
- Evidence for widespread GC-biased gene conversion in eukaryotes.Genome biology and evolution · 2012Article
- Quantitative trait locus (QTL) mapping reveals a role for unstudied genes in Aspergillus virulence.PloS one · 2011Article
- Analyses of pediatric isolates of Cryptococcus neoformans from South Africa.Journal of clinical microbiology · 2011Article
- Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
To construct a genetic linkage map of the heterothallic yeast, Cryptococcus neoformans (Filobasidiella neoformans), we crossed two mating-compatible strains and analyzed 94 progeny for the segregation of 301 polymorphic markers, consisting of 228 restriction site polymorphisms, 63 microsatellites, two indels, and eight mating-type (MAT)-associated markers. All but six markers showed no significant (P < 0.05) segregation distortion. At a minimum LOD score of 6.0 and a maximum recombination frequency of 0.30, 20 linkage groups were resolved, resulting in a map length of approximately 1500 cM. Average marker density is 5.4 cM (range 1-28.7 cM). Hybridization of selected markers to blots of electrophoretic karyotypes unambiguously assigned all linkage groups to chromosomes and led us to conclude that the C. neoformans genome is approximately 20.2 Mb, comprising 14 chromosomes ranging in size from 0.8 to 2.3 Mb, with a ratio of approximately 13.2 kb/cM averaged across the genome. However, only 2 of 12 ungrouped markers hybridized to chromosome 10. The hybridizations revealed at least one possible reciprocal translocation involving chromosomes 8, 9, and 12. This map has been critical to genome sequence assembly and will be essential for future studies of quantitative trait inheritance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.