ArticleEnvironmental health perspectives2004
Biomarkers in maternal and newborn blood indicate heightened fetal susceptibility to procarcinogenic DNA damage.
Article in Environmental health perspectives, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
71 citing papers in PubMed, 1 synthesis or guideline pooled it, 150 citations in OpenAlex.
- Pooled it
- Prenatal environmental risk for adolescent attention, thought, and substance use problems: A mixtures approach to coexposure and psychiatric comorbidities.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- Early life exposure to tobacco smoke and ovarian cancer risk in adulthood.International journal of epidemiology · 2021Article
- Prenatal air pollution exposure and neurodevelopment: A review and blueprint for a harmonized approach within ECHO.Environmental research · 2021Review
- Associations of prenatal exposure to polycyclic aromatic hydrocarbons with pubertal timing and body composition in adolescent girls: Implications for breast cancer risk.Environmental research · 2021Article
- Prenatal and Postnatal Cigarette Smoke Exposure Is Associated With Increased Risk of Exacerbated Allergic Airway Immune Responses: A Preclinical Mouse Model.Frontiers in immunology · 2021Article
- PAH-pollution effects on sensitive and resistant embryos: Integrating structure and function with gene expression.PloS one · 2021Article
- Prenatal exposure to polycyclic aromatic hydrocarbons modifies the effects of early life stress on attention and Thought Problems in late childhood.Journal of child psychology and psychiatry, and allied disciplines · 2020Article
- Cross-validation of biomonitoring methods for polycyclic aromatic hydrocarbon metabolites in human urine: Results from the formative phase of the Household Air Pollution Intervention Network (HAPIN) trial in India.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2020Article
- The effect of exposure to particulate matter during pregnancy on lower respiratory tract infection hospitalizations during first year of life.Environmental health : a global access science source · 2020Article
- Detection of BPDE-DNA adducts in human umbilical cord blood by LC-MS/MS analysis.Journal of food and drug analysis · 2019Article
- Effect of Benzo[a]pyrene-DNA Adduct in Cord Blood on the Neurodevelopment of 12-Month-Old Infants in Qingdao City.Neuropsychiatric disease and treatment · 2019Article
- Systematic developmental neurotoxicity assessment of a representative PAH Superfund mixture using zebrafish.Toxicology and applied pharmacology · 2018Article
- A novel method for source-specific hemoglobin adducts of nitro-polycyclic aromatic hydrocarbons.Environmental science. Processes & impacts · 2018Article
- Comparative developmental toxicity of a comprehensive suite of polycyclic aromatic hydrocarbons.Archives of toxicology · 2018Article
- Combined effects of prenatal exposure to polycyclic aromatic hydrocarbons and material hardship on child ADHD behavior problems.Environmental research · 2018Article
- Significant interactions between maternal PAH exposure and single nucleotide polymorphisms in candidate genes on B[ a ]P-DNA adducts in a cohort of non-smoking Polish mothers and newborns.Carcinogenesis · 2016Article
- Nrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio).Free radical biology & medicine · 2015Review
- Prenatal exposure to polycyclic aromatic hydrocarbons/aromatics, BDNF and child development.Environmental research · 2015Article
- Prenatal exposure to polycyclic aromatic hydrocarbons and cognitive dysfunction in children.Environmental science and pollution research international · 2015Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (BaP) are widespread air contaminants released by transportation vehicles, power generation, and other combustion sources. Experimental evidence indicates that the developing fetus is more susceptible than the adult to carcinogenic effects of PAHs, although laboratory studies in rodents suggest that the dose to fetal tissues is an order of magnitude lower than that to maternal tissues. To assess fetal versus adult susceptibility to PAHs and environmental tobacco smoke (ETS), we compared carcinogen-DNA adducts (a biomarker associated with increased cancer risk) and cotinine (a biomarker of tobacco smoke exposure) in paired blood samples collected from mothers and newborns in New York City. We enrolled 265 nonsmoker African-American and Latina mother-newborn pairs in New York City between 1997 and 2001 (estimated average ambient air BaP concentrations < 0.5 ng/m3). Despite the estimated 10-fold lower fetal dose, mean levels of BaP-DNA adducts as determined by high-performance liquid chromatography-fluorescence were comparable in paired New York City newborn and maternal samples (0.24 adducts per 10(8) nucleotides, 45% of newborns with detectable adducts vs. 0.22 per 10(8) nucleotides, 41% of mothers with detectable adducts). However, by the Wilcoxon signed-rank test, the levels in newborns were higher (p = 0.02). Mean cotinine was higher in newborns than in mothers (1.7 ng/mL, 47% detectable vs. 1.28 ng/mL, 44% detectable). Consistent with our prior study in a Caucasian Polish population, these results indicate increased susceptibility of the fetus to DNA damage and reduced ability to clear ETS constituents. The findings have implications for risk assessment, given the need to protect children as a sensitive subset of the population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.