ArticleEnvironmental health perspectives2004
Survivorship patterns of larval amphibians exposed to low concentrations of atrazine.
Article in Environmental health perspectives, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A qualitative meta-analysis reveals consistent effects of atrazine on freshwater fish and amphibians.Environmental health perspectives · 2010Pooled it
- Chronic dimethomorph exposure induced behaviors abnormalities and cognitive performance alterations in adult zebrafish (Toxicology reports · 2025Article
- Deleterious Biological Effects of Endocrine Disruptors: An Insight into Human Health Risks.Endocrine, metabolic & immune disorders drug targets · 2024Review
- Effects of Atrazine exposure on human bone marrow-derived mesenchymal stromal cells assessed by combinatorial assay matrix.Frontiers in immunology · 2023Article
- Comprehensive analysis of differences of NGenes and environment : the official journal of the Japanese Environmental Mutagen Society · 2021Article
- Life history traits and reproductive ecology of North American chorus frogs of the genus Pseudacris (Hylidae).Frontiers in zoology · 2021Review
- Genome Characteristics Reveal the Biocontrol Potential of Actinobacteria Isolated From Sugarcane Rhizosphere.Frontiers in microbiology · 2021Article
- Atrazine Exposure Influences Immunity in the Blue Dasher Dragonfly, Pachydiplax longipennis (Odonata: Libellulidae).Journal of insect science (Online) · 2018Article
- Do host-associated gut microbiota mediate the effect of an herbicide on disease risk in frogs?The Journal of animal ecology · 2018Article
- Effects of fluoranthene on the fitness-related traits and antioxidative defense in Lymantria dispar L.Environmental science and pollution research international · 2015Article
- Burrowing in the freshwater mussel Elliptio complanata is sexually dimorphic and feminized by low levels of atrazine.Journal of toxicology and environmental health. Part A · 2013Article
- Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses.Endocrine reviews · 2012Review
- The fungicide chlorothalonil is nonlinearly associated with corticosterone levels, immunity, and mortality in amphibians.Environmental health perspectives · 2011Article
- Global stressors and the global decline of amphibians: tipping the stress immunocompetency axis.Ecological research · 2011Article
- Low levels of the herbicide atrazine alter sex ratios and reduce metamorphic success in Rana pipiens tadpoles raised in outdoor mesocosms.Environmental health perspectives · 2010Article
- Parasites, info-disruption, and the ecology of fear.Oecologia · 2009Article
- Combined effects of atrazine and chlorpyrifos on susceptibility of the tiger salamander to Ambystoma tigrinum virus.EcoHealth · 2009Article
- The herbicide atrazine activates endocrine gene networks via non-steroidal NR5A nuclear receptors in fish and mammalian cells.PloS one · 2008Article
- Perturbation of organogenesis by the herbicide atrazine in the amphibian Xenopus laevis.Environmental health perspectives · 2008Article
- Exposure, postexposure, and density-mediated effects of atrazine on amphibians: breaking down net effects into their parts.Environmental health perspectives · 2006Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Amphibians can be exposed to contaminants in nature by many routes, but perhaps the most likely route is agricultural runoff in amphibian breeding sites. This runoff results in high-level pulses of pesticides. For example, atrazine, the most widely used pesticide in the United States, can be present at several parts per million in agricultural runoff. However, pesticide levels are likely to remain in the environment at low levels for longer periods. Nevertheless, most studies designed to examine the impacts of contaminants are limited to short-term (approximately 4 days) tests conducted at relatively high concentrations. To investigate longer-term (approximately 30 days) exposure of amphibians to low pesticide levels, we exposed tadpoles of four species of frogs--spring peepers (Pseudacris crucifer), American toads (Bufo americanus, green frogs (Rana clamitans), and wood frogs (Rana sylvatica)--at early and late developmental stages to low concentrations of a commercial preparation of atrazine (3, 30, or 100 ppb; the U.S. Environmental Protection Agency drinking water standard is 3 ppb). We found counterintuitive patterns in rate of survivorship. Survival was significantly lower for all animals exposed to 3 ppb compared with either 30 or 100 ppb, except the late stages of B. americanus and R. sylvatica. These survival patterns highlight the importance of investigating the impacts of contaminants with realistic exposures and at various developmental stages. This may be particularly important for compounds that produce greater mortality at lower doses than higher doses, a pattern characteristic of many endocrine disruptors.
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