Trial reportWiener klinische Wochenschrift2004
Human albumin and starch administration in critically ill patients: a prospective randomized clinical trial.
Trial report in Wiener klinische Wochenschrift, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 6 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Fluid resuscitation in adults with severe infection and sepsis: a systematic review and network meta-analysis.Frontiers in medicine · 2025Pooled it
- Randomised trials of human albumin for adults with sepsis: systematic review and meta-analysis with trial sequential analysis of all-cause mortality.BMJ (Clinical research ed.) · 2014Pooled it
- Albumin versus other fluids for fluid resuscitation in patients with sepsis: a meta-analysis.PloS one · 2014Pooled it
- Hydroxyethyl starch 130/0.38-0.45 versus crystalloid or albumin in patients with sepsis: systematic review with meta-analysis and trial sequential analysis.BMJ (Clinical research ed.) · 2013Pooled it
- Colloid solutions for fluid resuscitation.The Cochrane database of systematic reviews · 2012Pooled it
- Choice of fluids for resuscitation in children with severe infection and shock: systematic review.BMJ (Clinical research ed.) · 2010Pooled it
- Stable Nitroxide as Diagnostic Tools for Monitoring of Oxidative Stress and Hypoalbuminemia in the Context of COVID-19.International journal of molecular sciences · 2024Review
- Intravenous fluid therapy in accordance with kidney injury risk: when to prescribe what volume of which solution.Clinical kidney journal · 2023Review
- Effects of Albumin Supplements on In-Hospital Mortality in Patients with Sepsis or Septic Shock: A Systemic Review and Meta-Analysis.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- ["Intravascular space contracted-tissue space expanded": interstitial edema and fluid management in intensive care medicine].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2021Review
- Normal saline for intravenous fluid therapy in critically ill patients.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2018Review
- Fluid resuscitation in critically ill patients: a systematic review and network meta-analysis.Therapeutics and clinical risk management · 2018Article
- Relative survival benefit and morbidity with fluids in severe sepsis - a network meta-analysis of alternative therapies.Current drug safety · 2013Review
- Systematic review of randomized clinical trials on the use of hydroxyethyl starch for fluid management in sepsis.BMC emergency medicine · 2008Article
- [New approaches to intensive care for sepsis].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2005Review
- Why albumin may still work.Wiener klinische Wochenschrift · 2004Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine whether intravenous infusion of either human albumin or hydroxyethyl-starch (HES) in hypo-albuminemic critically ill may lead to an increase in colloid osmotic pressure and to a better clinical outcome, i.e. lower mortality and fewer complications, compared to fluid replacement with normal saline.
designProspective, randomized controlled clinical trial during 72 hours in 61 consecutively admitted severely ill patients. Randomisation took place by sealed envelope, kept outside of the hospital.
settingIntensive care unit of the Twenteborg Hospital, Almelo, The Netherlands. SUBJECTS: Sixty-three severely ill, hypo-albuminemic patients were selected; 27 patients had severe sepsis and 36 were post-surgical patients with SIRS. Two patients died shortly after randomization, 15 patients received human albumin, 15 HES 500 and 15 HES 1000 ml, and 16 saline.
interventionsThe patients were randomized to receive 300 ml human albumin (20%) per day, or 1000 ml normal saline per day, or 500 ml or 1000 ml HES per day, all for 72 hours.
main outcome measuresThe primary outcome was plasma colloid osmotic pressure (COP). Secondary endpoints were fluid balance and the development of pulmonary edema.
resultsAdministration of human albumin was effective in raising COP (P<0.001 on day 2 and day 3, compared to saline and HES). Neither fluid balances nor the development of peripheral or pulmonary edema were different between the groups. Mortality as well as length of stay at ICU were slightly higher in the group receiving human albumin, although not statistically significant.
conclusionRaising colloid osmotic pressure with human albumin in hypoalbuminemic patients is not associated with improvement of the clinical outcome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.