ReviewReproductive biology and endocrinology : RB&E2004
Trophoblast gene expression: transcription factors in the specification of early trophoblast.
Review in Reproductive biology and endocrinology : RB&E, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 62 citations in OpenAlex.
- Evaluation of day 5 versus day 6 blastocyst biopsy in preimplantation genetic testing: clinical and neonatal outcomes.Frontiers in endocrinology · 2025Article
- CRISPR screening in human trophoblast stem cells reveals both shared and distinct aspects of human and mouse placental development.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Generation of Trophoblast-Like Cells From Hypomethylated Porcine Adult Dermal Fibroblasts.Frontiers in veterinary science · 2021Article
- MicroRNA regulation of murine trophoblast stem cell self-renewal and differentiation.Life science alliance · 2020Article
- Transcriptomic analysis reveals differential gene expression, alternative splicing, and novel exons during mouse trophoblast stem cell differentiation.Stem cell research & therapy · 2020Article
- Optimization of in vitro trophoblast assay for real-time impedimetric sensing of trophoblast-erythrocyte interactions in Plasmodium falciparum malaria.Analytical and bioanalytical chemistry · 2020Article
- Identification of Novel Placentally Expressed Aspartic Proteinase in Humans.International journal of molecular sciences · 2017Article
- Transcriptional reprogramming and chromatin remodeling accompanies Oct4 and Nanog silencing in mouse trophoblast lineage.Stem cells and development · 2014Article
- Stress responses at the endometrial-placental interface regulate labyrinthine placental differentiation from trophoblast stem cells.Reproduction (Cambridge, England) · 2013Review
- Embryonic stem cell-derived trophoblast differentiation: a comparative review of the biology, function, and signaling mechanisms.The Journal of endocrinology · 2013Review
- Failure of extra-embryonic progenitor maintenance in the absence of dosage compensation.Development (Cambridge, England) · 2012Article
- In vitro culture of mouse embryos reduces differential gene expression between inner cell mass and trophectoderm.Reproductive sciences (Thousand Oaks, Calif.) · 2012Article
- Paracrine and epigenetic control of trophectoderm differentiation from human embryonic stem cells: the role of bone morphogenic protein 4 and histone deacetylases.Stem cells and development · 2011Article
- Trophoblast stem cells.Biology of reproduction · 2011Review
- Functional genomics of 5- to 8-cell stage human embryos by blastomere single-cell cDNA analysis.PloS one · 2010Article
- Trophoblast stem cells: models for investigating trophectoderm differentiation and placental development.Endocrine reviews · 2009Review
- Combinatorial roles of protein kinase A, Ets2, and 3',5'-cyclic-adenosine monophosphate response element-binding protein-binding protein/p300 in the transcriptional control of interferon-tau expression in a trophoblast cell line.Molecular endocrinology (Baltimore, Md.) · 2008Article
- Effects of fgf2 and oxygen in the bmp4-driven differentiation of trophoblast from human embryonic stem cells.Stem cell research · 2007Article
- Epigenetic activation of the human growth hormone gene cluster during placental cytotrophoblast differentiation.Molecular and cellular biology · 2007Article
- Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is required for branching morphogenesis in the chorioallantoic placenta.Molecular and cellular biology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Azone of trophoblast specification is established when the embryo is a morula, presumably reflecting a unique combination of transcription factors in that zone of cells and the influence of various environmental cues and growth factors on them. A key first step in this process of specification is the down-regulation of Oct4, a transcription factor that acts as a negative regulator of trophoblast specification and of genes normally up-regulated as the trophectoderm first forms. The transcription factors believed to have a positive association with trophectoderm specification have been inferred primarily in two ways: by their expression patterns in embryos, ES cells and TS cells and by the consequences of gene disruption on embryonic development. Many of these transcription factors also control the expression of genes characteristically expressed in trophoblast but not in the epiblast, primitive endoderm and their derivatives. ES and TS cells from the mouse and other species are beginning to provide insights into the changes in gene expression that accompany lineage specification and the subsequent post-specification events that lead to functional trophoblast derivatives.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.