Evidence map›Paper›PMID 15236654›Full record

ReviewReproductive biology and endocrinology : RB&E2004

Trophoblast-uterine interactions at implantation.

John D Aplin, Susan J Kimber

Open access · goldAbstract readReview
In one paragraph

Review in Reproductive biology and endocrinology : RB&E, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 179 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Modelling mammalian implantationAnimal reproduction · 2026
    Review
  5. Implantation Failure: Where to Look Up?Journal of clinical medicine · 2025
    Review
  6. Review
  7. Review
  8. Review
  9. Early Embryonic Development in Agriculturally Important Species.Animals : an open access journal from MDPI · 2024
    Review
  10. Circulating miRNAs and Preeclampsia: From Implantation to Epigenetics.International journal of molecular sciences · 2024
    Review
  11. Integrins and their potential roles in mammalian pregnancy.Journal of animal science and biotechnology · 2023
    Review
  12. Article
  13. Review
  14. Early human trophoblast development: from morphology to function.Cellular and molecular life sciences : CMLS · 2022
    Review
  15. Article
  16. Article
  17. Review
  18. Early pregnancy loss: the default outcome for fertilized human oocytes.Journal of assisted reproduction and genetics · 2020
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

John D AplinAcademic Unit of Obstetrics and Gynaecology, University of Manchester, St Mary's Hospital, Manchester M13 0JH, UK. john.aplin@man.ac.uk
Susan J Kimber
University of Manchester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Implantation of the embryo in the uterus is a critical and complex event and its failure is widely considered an impediment to improved success in assisted reproduction. Depending on whether placentation is invasive or superficial (epitheliochorial), the embryo may interact transiently or undergo a prolonged adhesive interaction with the uterine epithelium. Numerous candidate interactions have been identified, and there is good progress on identifying gene networks required for early placentation. However no molecular mechanisms for the epithelial phase are yet firmly established in any species. It is noteworthy that gene ablation in mice has so far failed to identify obligatory initial molecular events.

Indexed as

AnimalsEmbryo ImplantationFemaleHumansPregnancyTrophoblastsUterus

Identifiers

PMID15236654
PMCPMC471567
OpenAlexW2143555451

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.