ArticleThe Journal of comparative neurology2004
Expression of calcium transporters in the retina of the tiger salamander (Ambystoma tigrinum).
Article in The Journal of comparative neurology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Dysfunction of α2δ4 leads to photoreceptor degeneration through disrupted synaptic mitochondria and calcium crosstalk.Cell death & disease · 2026Article
- TRPV4 and TRPC1 channels mediate the response to tensile strain in mouse Müller cells.Cell calcium · 2022Article
- The RNA-binding protein and stress granule component ATAXIN-2 is expressed in mouse and human tissues associated with glaucoma pathogenesis.The Journal of comparative neurology · 2022Article
- Store-Operated Calcium Entry in Müller Glia Is Controlled by Synergistic Activation of TRPC and Orai Channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Weak endogenous Ca2+ buffering supports sustained synaptic transmission by distinct mechanisms in rod and cone photoreceptors in salamander retina.Physiological reports · 2015Article
- Ca2+ Diffusion through Endoplasmic Reticulum Supports Elevated Intraterminal Ca2+ Levels Needed to Sustain Synaptic Release from Rods in Darkness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Role of intracellular calcium stores in hair-cell ribbon synapse.Frontiers in cellular neuroscience · 2014Review
- Chloride currents in cones modify feedback from horizontal cells to cones in goldfish retina.The Journal of physiology · 2012Article
- Distribution and function of polycystin-2 in mouse retinal ganglion cells.Neuroscience · 2012Article
- Calcium stores in vertebrate photoreceptors.Advances in experimental medicine and biology · 2012Review
- The dynamic architecture of photoreceptor ribbon synapses: cytoskeletal, extracellular matrix, and intramembrane proteins.Visual neuroscience · 2011Review
- The molecular architecture of ribbon presynaptic terminals.Molecular neurobiology · 2009Review
- Anatomical and neurochemical characterization of dopaminergic interplexiform processes in mouse and rat retinas.The Journal of comparative neurology · 2008Article
- Kinetics of synaptic transmission at ribbon synapses of rods and cones.Molecular neurobiology · 2007Review
- The dynamic range and domain-specific signals of intracellular calcium in photoreceptors.Neuroscience · 2006Article
- Scotopic visual signaling in the mouse retina is modulated by high-affinity plasma membrane calcium extrusion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Calcium-induced calcium release in rod photoreceptor terminals boosts synaptic transmission during maintained depolarization.The European journal of neuroscience · 2006Article
- Compartmentalization of calcium entry pathways in mouse rods.The European journal of neuroscience · 2005Article
- Serca isoform expression in the mammalian retina.Experimental eye research · 2005Article
- Synaptic transmission at retinal ribbon synapses.Progress in retinal and eye research · 2005Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Changes in intracellular calcium concentration, [Ca2+]i, modulate the flow of visual signals across all stages of processing in the retina, yet the identities of Ca2+ transporters responsible for these changes are still largely unknown. In the current study, the distribution of plasma membrane and intracellular Ca2+ transporters in the retina of tiger salamander, a model system for physiological studies of retinal function, was determined. Plasma membrane calcium ATPases (PMCAs), responsible for high-affinity Ca2+ extrusion, were highly expressed in the salamander retina. PMCA isoforms 1, 2, and 4 were localized to photoreceptors, whereas the inner retina expressed all four isoforms. PMCA3 was expressed in a sparse population of amacrine and ganglion neurons, whereas PMCA2 was expressed in most amacrine and ganglion cells. Na+/Ca2+ exchangers, a high-capacity Ca2+ extrusion system, were expressed in the outer plexiform layer and in a subset of inner nuclear and ganglion layer cells. Intracellular Ca2+ store transporters were also represented prominently. SERCA2a, a splice variant of the sarcoplasmic-endoplasmic Ca2+ ATPase, was found mostly in photoreceptors, whereas SERCA2b was found in the majority of retinal neurons and in glial cells. The predominant endoplasmic reticulum (ER) Ca2+ channels in the salamander retina are represented by the isoform 2 of the IP3 receptor family and the isoform 2 of the ryanodine receptor family. These results indicate that Ca2+ transporters in the salamander retina are expressed in a cell type-specific manner.
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