ArticleOncogene2004
Nuclear localization of Tob is important for regulation of its antiproliferative activity.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The trial behind it
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Who cites it
30 citing papers in PubMed, 58 citations in OpenAlex.
- Tob Regulates the Timing of Sleep Onset at Night inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- TOB1 and TOB2 mark distinct RNA processing granules in differentiating lens fiber cells.Journal of molecular histology · 2024Article
- TOB1 modulates the decidualization of human endometrial stromal cells via the Notch pathway.Journal of assisted reproduction and genetics · 2021Article
- TOB1 suppresses proliferation in K-Ras wild-type pancreatic cancer.Cancer medicine · 2020Article
- High expression of Tob1 indicates poor survival outcome and promotes tumour progression via a Wnt positive feedback loop in colon cancer.Molecular cancer · 2018Article
- Prognostic value of transducer of ErbB2.1 (TOB1) expression in patients with gastric cancer: tissue microarray analysis.International journal of clinical and experimental pathology · 2018Article
- Decreased TOB1 expression and increased phosphorylation of nuclear TOB1 promotes gastric cancer.Oncotarget · 2017Article
- BTG1 might be employed as a biomarker for carcinogenesis and a target for gene therapy in colorectal cancers.Oncotarget · 2017Article
- Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitis.Scientific reports · 2016Article
- MiR-4295 promotes cell growth in bladder cancer by targeting BTG1.American journal of translational research · 2016Article
- Transducer of ERBB2.1 (TOB1) as a Tumor Suppressor: A Mechanistic Perspective.International journal of molecular sciences · 2015Review
- The roles of BTG3 expression in gastric cancer: a potential marker for carcinogenesis and a target molecule for gene therapy.Oncotarget · 2015Article
- BTG1 expression correlates with pathogenesis, aggressive behaviors and prognosis of gastric cancer: a potential target for gene therapy.Oncotarget · 2015Article
- Diversity of clinical implication of B-cell translocation gene 1 expression by histopathologic and anatomic subtypes of gastric cancer.Digestive diseases and sciences · 2015Article
- The role of antiproliferative gene Tob1 in the immune system.Clinical & experimental neuroimmunology · 2014Article
- Decreased expression of BTG3 was linked to carcinogenesis, aggressiveness, and prognosis of ovarian carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- BTG1 expression correlates with the pathogenesis and progression of ovarian carcinomas.International journal of molecular sciences · 2013Article
- C. elegans FOG-3/Tob can either promote or inhibit germline proliferation, depending on gene dosage and genetic context.Oncogene · 2013Article
- Article
- The role of the TOB1 gene in growth suppression of hepatocellular carcinoma.Oncology letters · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
tobis a member of an antiproliferative gene family that includes btg1, pc3/tis21/btg2, pc3b, ana/btg3, and tob2. Exogenous overexpression of the family proteins suppresses cell proliferation. These proteins participate in transcriptional regulation of several genes. Here, we show that Tob is a nuclear protein that is imported into the nucleus through a nuclear localization signal (NLS)-mediated mechanism. Mutation in the NLS sequence of Tob affects its nuclear localization and impairs antiproliferative activity. Additionally, Tob contains a nuclear export signal (NES). In oncogenic ErbB2-transformed cells, nuclear export of Tob is facilitated by NES-mediated mechanism, resulting in decrease of its antiproliferative activity. These results indicate that regulation of nuclear localization of Tob is important for its antiproliferative activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.