ArticleInternational journal of gastrointestinal cancer2003
Genome-wide search for loss of heterozygosity in Chinese patients with sporadic colorectal cancer.
Article in International journal of gastrointestinal cancer, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Knowledge Graph Analysis of Human Health Research Related to Climate Change.International journal of environmental research and public health · 2020Article
- MicroRNA-34a functions as a tumor suppressor by directly targeting oncogenic PLCE1 in Kazakh esophageal squamous cell carcinoma.Oncotarget · 2017Article
- Elevated expression patterns and tight correlation of the PLCE1 and NF-κB signaling in Kazakh patients with esophageal carcinoma.Medical oncology (Northwood, London, England) · 2014Article
- No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer.World journal of gastroenterology · 2009Article
- Refined mapping of loss of heterozygosity on 1q31.1-32.1 in sporadic colorectal carcinoma.World journal of gastroenterology · 2008Article
- Loss of heterozygosity analyzed by single nucleotide polymorphism array in cancer.World journal of gastroenterology · 2005Review
- Detailed deletion mapping of loss of heterozygosity on 22q13 in sporadic colorectal cancer.World journal of gastroenterology · 2005Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In an attempt to integrally investigate the loss of tumor suppressor genes and search for putative suppressor loci associated with tumor occurrence and progression, we conducted a genome-wide loss of hetero zygosity (LOH) study of 83 tumor samples obtained from Chinese patients with sporadic colorectal cancer. We employed 400 fluorescence-labeled microsatellite marker primers to amplify the corresponding loci of the genomic DNA and then electrophoresed the polymerase chain reaction products and analyzed the fluorescent signals. The LOH frequencies were high (>35%) but were not associated with the tumor stage and progression in 20 loci, including the regions where TP53, E-cadherin, deleted in colorectal carcinoma (DCC), phosphatase and tensin homolog deleted on chromosome 10 (PTEN), mothers against decapentaplegic, Drosophila, homolog of 2 (MADH2) and mothers against decapentaplegic, Drosophila, homolog of 4 (MADH4) reside. Loss of other loci, including two narrow regions on chromosome 2, was found to relate to the tumor stage, suggesting that this genomic instability may contribute to tumor progression.
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